This follow-up study to ACTG 175 will determine the influence of virus load, CD4 cell counts, biologic phenotype, and the presence of symptomatic HIV disease on the response to a new therapeutic regimen, on the kinetics of viral replication, and on the rate of emergence of 3TC-associated resistance mutation at codon 184. It will compare the efficacy of continuing ZDV/ddI or ZDV/ddC versus adding 3TC or switching to ZDV/3TC. M01RR000960490 The primary objective of this study is to determine whether Panorex, a monoclonal antibody against glycoproteins on the cell surface of adenocarcinomas, given in combination with 5-FU based chemotherapy improves survival relative to 5-FU-based chemotherapy alone in patients with surgically resected stage III (Duke's C) adenocarcinoma of the colon.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
37
Fiscal Year
1998
Total Cost
Indirect Cost
Name
New York University
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
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