Double-blind, vehicle-controlled study of the effectiveness of topical isotretinoin cream in retarding or reversing structural changes associated with photodamage of the skin. Preliminary studies by others has indicated possible increase in the number of fibroblasts and collagen production. Our data have confirmed this and, for the first time, have demonstrated that topical retoinoids can reduce the number of premalignant actinic keratose in sun-damaged skin. This study has been completed.

Project Start
Project End
Budget Start
Budget End
Support Year
27
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Rockefeller University
Department
Type
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
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