Patients screened for HDL cholesterol, apo A-I and Apo A-II levels. HDL turnover assessed in vivo to determine synthetic and catabolic rate of HDL apolipoproteins. Gel electrophoresis, immunoblotting and mass spectrometry to assess apolipoprotein and lipoprotein lipase structure with molecular DNA analysis where indicated. Nutritional perturbations of HDL metabolism assessed by restudying patients on a low fat diet.

Project Start
Project End
Budget Start
Budget End
Support Year
27
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Rockefeller University
Department
Type
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
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