Recent evidence suggests that CD8+ T-lymphocytes of the Vbeta 3 or Vbeta 13.1 subsets are activated and clonally expanded in skin lesions of psoriasis vulgaris. This study is a clinical and pathological examination of potential disease-mediating functions of these T-cell subsets. The study involves administration of a bivalent peptide vaccine containing epitopes from Vbeta 3 and Vbeta 13.1 constant regions to patients with chronic psoriasis vulgaris. Part A of the study is concerned with clinical evaluation of outcomes. Part B of the study is concerned with assessment of T-lymphocyte subsets in psoriatic skin lesions before and during treatment, as assessed in skin biopsies.

Project Start
Project End
Budget Start
Budget End
Support Year
33
Fiscal Year
1996
Total Cost
Indirect Cost
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