To determine the absorption characteristics of another drug, ranitidine, which was shown in the early development work to have poor bioavialability when a sustained release formulation was administered. For this study a 4.5 meter multilumen tube was designed. This tube allowed for the direct instillation of the injectable formulation of the drug into the stomach, jejunum, and cecum. With timed blood sampling, the pharmacokinetics of the drug were determined after each dose.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
3M01RR000211-33S2
Application #
6116850
Study Section
Project Start
1996-12-01
Project End
1999-08-14
Budget Start
Budget End
Support Year
33
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Tennessee Health Science Center
Department
Type
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163
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