This protocol will test the hypnotic efficacy of low-dose (physiological replacement) melatonin for the treatment of age-related insomnia. Each subject will be treated for two-week blocks (in rotation) with placebo and three different melatonin dosing strategies that produce unique pharmacokinetic profiles. Response variables will include measures of sleep, daytime alertness, and circadian phase. On the last night of each treatment arm, subjects will be admitted for pharmacokineetic, temperature sleep & circadian phase assessment.

Project Start
1997-12-01
Project End
1998-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
32
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
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