We will test: 1. There is an inverse correlation between birthweight and adult blood pressure. 2. Individual in the lowest tertile of birthweight will show salt-sensitivity as shown by their blood pressure and plasma hormone levels compared to other tertiles of birth weight. 3. The proposed mechanism of action is that individuals with a low birthweight have been """"""""programmed"""""""" in utero to inappropriately maintain or elevate renin and/or aldosterone plasma levels in respone to a sodium challenge, whereas normal individuals will suppress renin and/or aldosterone t increase natriuresis and polyuria.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000334-34
Application #
6411460
Study Section
Special Emphasis Panel (ZRR1)
Project Start
1976-12-01
Project End
2004-11-30
Budget Start
Budget End
Support Year
34
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
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