This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthmatic children and adolescents living in low-income, inner-city communities are a high-risk population characterized by increased asthma-related morbidity and mortality. There is an important need to find strategies for improving long term asthma control in this population. Exhaled nitric oxide (eNO), a marker of bronchial inflammation, appears to be increased during periods of uncontrolled asthma and decreased during treatment with medicines for asthma. Companies have recently started to market equipment to measure eNO as a means of monitoring and enhancing asthma control, but no randomized clinical trial has yet addressed the question of whether such monitoring improves asthma outcomes. The purpose of this study is to determine whether selection of asthma therapy on the basis of eNO measurements combined with clinical parameters improves asthma control compared with therapy chosen solely on the basis of clinical parameters.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000533-38
Application #
7379501
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2005-12-01
Project End
2006-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
38
Fiscal Year
2006
Total Cost
$97,282
Indirect Cost
Name
Boston University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
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