This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Antioxidant vitamins will have a beneficial role in improving heart function in patients with AL amyloidosis and cardiac involvement. Animal heart model studies ahve shown deleterious effects of AL amyloid fibrils to heart tissue related to increased oxidative stress. Experimental Design: A randomized double-blind, placebo controlled pilot trial evaluating the effects of antioxidants on cardiac function in patients with AL amyloidosis. Patients with AL amyloidosis will have baseline cardiac studies. Those with cardiac involvement will be randomized to receive either vitamin C and vitamin E or placebo for 12 weeks time. The primary endpoint to evaluate cardiac function will be change in BNP. Secondary endpoints will be changed echocardiogram and change in clinical status.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000533-39
Application #
7606259
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-01-03
Project End
2007-11-30
Budget Start
2007-01-03
Budget End
2007-11-30
Support Year
39
Fiscal Year
2007
Total Cost
$6,251
Indirect Cost
Name
Boston University
Department
Administration
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
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