This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of this study is that glucose output by the liver increases with advancing age secondary to hepatic insulin resistance, independent of body weight or level of physical activity, thus leading to a predisposition of edlderly individuals to develop diabetes mellitus or impaired glucose tolerance.
The aims of this study are: 1) to quantify hepatic glucose output under fasting conditions in both younger and older humans in order to understand the changes in glucose homeostasis associated with aging. 2) to determine the substrate sources for glucose synthesis in the liver and correlate this data with hepatic glucose production as a means of detecting the alterations in intermediary metabolism that may underlie metabolic diseases, such as diabetes mellitus, that are associated with advancing age.
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