This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In subjects with Type 2 diabetes with inadequate glycemic control on oral therapy study 1. To evaluate the effect of colesevelam 3.8 g administered daily for 12 weeks, on hepatic insulin sensitivity. 2. To evaluate the effect of colesevelam 3.8g administered daily for 12 weeks on peripheral insulin sensitivity.
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