EXCEED THE SPACEPROVIDED.Clinical investigation at the UVA GCRC is in its 31st year, and we request support for years 33-37. OurGCRC has longstanding strengths in neuroendocrinology, allergy, reproductive medicine, immunotherapy ofcancer, and diabetes. These persist. In the past 2 years we have attracted a new cadre of GCRCinvestigators from Cardiology, vascular biology, and from the Center for Alternative Medicine program in theSchool of Nursing. With the recent recruitment of new research intensive leadership in our divisions ofCardiovascular Medicine, Hematology and Oncology, and our Department of Psychiatry and BehavioralMedicine, we anticipate continued growth and vitality of our research programs. In the past 2 years, wehave also had major upgrades in our core assay program thereby facilitating sample throughput to>100,000/yr while freeing personnel time to implement additional analytical services. We have initiated a newGCRC imaging laboratory to allow studies of endothelial dysfunction in setting of diabetes, insulin resistance,and PCOS and microvascular perfusion in multiple organs including heart, muscle and kidney.The UVA GCRC has enjoyed an excellent record of productivity (>170 publications over the past 4 yrs). Itsexercise, informatics and biomathematics cores have been national leaders in their innovative support forclinicalinvestigations. The GCRC enjoys a stable core of NIH-funded established investigators and isdeveloping through our educational and mentoring programs another generation of skilled clinicalinvestigators. We are particularly proud of our CAP and K award winners.During the last 3 years, we have seen (as has been a national trend) a growth in outpatient studies whileinpatient studies, particularly those that have involved 24 hr blood sampling, have decreased. We have pro-actively begun working with the UVA Health System to plan a redesigned GCRC with expanded space andgreater accessibility for outpatients that would accommodate current and projected usage.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
General Clinical Research Centers Program (M01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CR-8 (01))
Program Officer
Filart, Rosemarie
Project Start
Project End
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Support Year
Fiscal Year
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University of Virginia
Internal Medicine/Medicine
Schools of Medicine
United States
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Campbell, Garland A; Patrie, James T; Gaylinn, Bruce D et al. (2018) Oral ghrelin receptor agonist MK-0677 increases serum insulin-like growth factor 1 in hemodialysis patients: a randomized blinded study. Nephrol Dial Transplant 33:523-530
Malin, Steven K; Rynders, Corey A; Weltman, Judy Y et al. (2016) Endothelial function following glucose ingestion in adults with prediabetes: Role of exercise intensity. Obesity (Silver Spring) 24:1515-21
Rynders, Corey A; Weltman, Judy Y; Malin, Steven K et al. (2016) Comparing Simple Insulin Sensitivity Indices to the Oral Minimal Model Postexercise. Med Sci Sports Exerc 48:66-72
Hu, Yinin; Kim, Helen; Blackwell, Christopher M et al. (2015) Long-term outcomes of helper peptide vaccination for metastatic melanoma. Ann Surg 262:456-64; discussion 462-4
Marozkina, Nadzeya V; Wang, Xin-Qun; Stsiapura, Vitali et al. (2015) Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. Eur Respir J 45:87-97
Nass, Ralf; Nikolayev, Alexander; Liu, Jianhua et al. (2015) The level of circulating octanoate does not predict ghrelin O-acyl transferase (GOAT)-mediated acylation of ghrelin during fasting. J Clin Endocrinol Metab 100:E110-3
Argo, Curtis K; Patrie, James T; Lackner, Carolin et al. (2015) Effects of n-3 fish oil on metabolic and histological parameters in NASH: a double-blind, randomized, placebo-controlled trial. J Hepatol 62:190-7
Chyun, Deborah A; Wackers, Frans J Th; Inzucchi, Silvio E et al. (2015) Autonomic dysfunction independently predicts poor cardiovascular outcomes in asymptomatic individuals with type 2 diabetes in the DIAD study. SAGE Open Med 3:2050312114568476
Nass, Ralf; Farhy, Leon S; Liu, Jianhua et al. (2014) Age-dependent decline in acyl-ghrelin concentrations and reduced association of acyl-ghrelin and growth hormone in healthy older adults. J Clin Endocrinol Metab 99:602-8
Hu, Yinin; Petroni, Gina R; Olson, Walter C et al. (2014) Immunologic hierarchy, class II MHC promiscuity, and epitope spreading of a melanoma helper peptide vaccine. Cancer Immunol Immunother 63:779-86

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