This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Patients with heart failure compared to people without heart failure have exaggerated increases in sympathetic nerve activity during exercise, which may contribute to exercise intolerance, shortness of breath, and fluid retention. The purpose of this study is to determine if, by blocking the effects of compounds released by your body during arm exercise with aminophylline, the increase in sympathetic nerve activity will be blocked as well. Aminophylline is a FDA-approved drug for asthma. However, it is not approved for use in the treatment of heart failure or its symptoms. We hope that this research will help us understand why patient with heart failure cannot exercise very much.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000865-34
Application #
7606745
Study Section
Special Emphasis Panel (ZRR1-CR-4 (01))
Project Start
2007-02-21
Project End
2007-11-30
Budget Start
2007-02-21
Budget End
2007-11-30
Support Year
34
Fiscal Year
2007
Total Cost
$4,809
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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