This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Many people with SLE have high levels of lipids (fats) called cholesterol in their blood. Cholesterol can build up in the blood vessels, and the vessels can become hardened and inflamed (thickened). This condition is called atherosclerosis. People with SLE are at high risk for developing atherosclerosis. Atherosclerosis can occur in people with SLE even if they do not have high cholesterol. Atherosclerosis increases the risk of heart attack, stroke, problems with circulation, and may shorten lifespan. This study is being done to find out if a drug called atorvastatin (Lipitor ) will lower cholesterol, decrease inflammation, and lessen heart, stroke, and circulatory problems in people from 10 through 19 years of age with SLE.This study will test whether or not atorvastatin will work better than a placebo (something that looks like the study drug but has no effect on the body) at slowing the process of atherosclerosis in children and teenagers with SLE when used with other cholesterol-lowering strategies.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
2M01RR000865-34
Application #
7606784
Study Section
Special Emphasis Panel (ZRR1-CR-4 (01))
Project Start
2007-02-21
Project End
2007-11-30
Budget Start
2007-02-21
Budget End
2007-11-30
Support Year
34
Fiscal Year
2007
Total Cost
$1,718
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Ellsworth, G B; Lensing, S Y; Ogilvie, C B et al. (2018) A delayed dose of quadrivalent human papillomavirus vaccine demonstrates immune memory in HIV-1-infected men. Papillomavirus Res 6:11-14
Goldman, Noreen; Glei, Dana A; Weinstein, Maxine (2018) Declining mental health among disadvantaged Americans. Proc Natl Acad Sci U S A 115:7290-7295
Dean, Andy C; Morales, Angelica M; Hellemann, Gerhard et al. (2018) Cognitive deficit in methamphetamine users relative to childhood academic performance: link to cortical thickness. Neuropsychopharmacology 43:1745-1752
Nersesian, Paula V; Han, Hae-Ra; Yenokyan, Gayane et al. (2018) Loneliness in middle age and biomarkers of systemic inflammation: Findings from Midlife in the United States. Soc Sci Med 209:174-181
Glei, Dana A; Goldman, Noreen; Ryff, Carol D et al. (2018) Physical Function in U.S. Older Adults Compared With Other Populations: A Multinational Study. J Aging Health :898264318759378
Stephan, Yannick; Sutin, Angelina R; Bayard, Sophie et al. (2018) Personality and sleep quality: Evidence from four prospective studies. Health Psychol 37:271-281
Green, Shulamite A; Hernandez, Leanna M; Bowman, Hilary C et al. (2018) Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues. Dev Cogn Neurosci 29:127-139
Chung, Joon (2017) Social support, social strain, sleep quality, and actigraphic sleep characteristics: evidence from a national survey of US adults. Sleep Health 3:22-27
Glei, Dana A; Goldman, Noreen; Ryff, Carol D et al. (2017) Can we determine whether physical limitations are more prevalent in the US than in countries with comparable life expectancy? SSM Popul Health 3:808-813
Scherzer, Rebecca; Heymsfield, Steven B; Rimland, David et al. (2017) Association of serum albumin and aspartate transaminase with 5-year all-cause mortality in HIV/hepatitis C virus coinfection and HIV monoinfection. AIDS 31:71-79

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