This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.In Type 1 diabetes, islet cells in the pancreas, which make insulin, are thought to be destroyed in an immune response. Islet cell transplantation is a procedure that is being tested as an experimental therapy in individuals with difficult to control Type 1 diabetes who are already on immunosuppression following a kidney transplant. In this protocol, islet cells are harvested from a donor and cultured for infusion. This is an open label, feasibility study whose primary purpose is to test whether islet transplantation results seen in Edmonton, Canada can be repeated in immunosuppressed kidney transplant patients and to test the safety of this investigational procedure. The study will consist of a screening evaluation, the treatment phase, and a follow-up phase lasting approximately 12 months.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR001032-32
Application #
7606916
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-04-01
Project End
2008-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
32
Fiscal Year
2007
Total Cost
$4,107
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
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