This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Study to investigate age-dependent estrogen feedback on the pituitary/hypothalamic axis using PET scanning. The main hypothesis is that effects will be greater in older than in younger women and that high dose gonadal steroids will have a greater pituitary effect and that this effect will be greater in older subjects. Two groups of women each 45-55 and 70-80 will be admitted to the GCRC for 5 days for graded estradiol and progesterone infusions. PET scanning will be done at timed intervals and will be the main endpoint.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR001066-30
Application #
7607027
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-12-01
Project End
2007-11-30
Budget Start
2006-12-01
Budget End
2007-11-30
Support Year
30
Fiscal Year
2007
Total Cost
$26,040
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
Venditti, E M; Tan, K; Chang, N et al. (2018) Barriers and strategies for oral medication adherence among children and adolescents with Type 2 diabetes. Diabetes Res Clin Pract 139:24-31
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