This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.
Specific Aims /Objectives:Children undergoing stem cell transplantation often require parenteral nutrition to provide adequate calories and protein due to severe mucositis and other gastrointestinal complication of the preparative regimen. Accurate provision of energy may reduce complications related to overfeeding or underfeeding. We hypothesize that changes in body composition during SCT affect REE, and that the standard approach to nutritional management of these patients may lead to overfeeding. We propose a prospective, randomized controlled trial to compare the nutritional effects of the standard method of nutritional support with an approach in which energy intake is provided to exactly meet resting energy expenditure as measured by indirect calorimetry.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR002172-25
Application #
7607255
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-04-01
Project End
2008-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
25
Fiscal Year
2007
Total Cost
$110,824
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
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Cousminer, Diana L; Widén, Elisabeth; Palmert, Mark R (2016) The genetics of pubertal timing in the general population: recent advances and evidence for sex-specificity. Curr Opin Endocrinol Diabetes Obes 23:57-65
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