To compare the fficacy of lamivudine vs. placebo vs. lamivudine followed by the combination of intron A plus lamivudine in patients with chronic hepatitis B infection who are interferon alpha non-responders. There will be two primary efficacy variables: histological response (for cmparison of the monotherapy regimes) and seroconversion rates (for the comparison of the placebo and comb-ination reginesm). Complete or partial normalization of serum alanine amino-transferase (ALT) and HBsAg seroconversion will be secondary markers of efficacy

Project Start
1998-12-01
Project End
1999-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
15
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Type
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
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