This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to evaluate the role of insulin resistance in the development of Type 2 diabetes and the associated medical conditions. Understanding the action of insulin in persons with and without a family history of diabetes may help to understand the basis of the disease and lead to new treatment options for people with diabetes or at risk of developing the dis
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