This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The purpose of this research study is to collect, purify, study, and store a large amount of CD34+ cells collected from either the bone marrow or the peripheral blood from patients with Fanconi anemia before severe bone marrow failure occurs. Subjects will be enrolled on the study for approximately one to three weeks, depending upon the harvest condition. After a bone marrow harvest or the cytokine mobilized peripheral blood collection, CD34+ cells will be purified using an experimental device called the CliniMACS. Some of the purified CD34+ cells will be used for study in the laboratory. The majority of cells (85% or more) will be frozen and stored indefinitely for future use, including reinfusion back into the subject as part of other studies designed to help treat Fanconi anemia.
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