Previous studies from our laboratory suggested the possible importance of the Vitamin k-dependent procoagulant proteins in the thrombotic process that is involved in premature ischemic heart disease (IHD). This study proposes to examine whether an elevated plasma prothrombin level, associated with a variant prothrombin gene, is a risk factor for the development of premature IHD. The prothrombin gene mutation or variant is a G to A nucleotide transition at 20210 in the 3'untranslated(3'-UTR) region of the prothrombin gene, which is associated with a 25-30% increase in plasma prothrombin activity and with 3-fold increased risk of deep venous thrombosis. Other objectives of the proposal will be to prove whether this increase in prothrombin activity is associated with lipid metabolism or with an increase in any of the other three procoagulant Vitamin K-dependent proteins, in order to clarify the mechanism responsible for the elevated plasma prothrombin activity.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR010710-03
Application #
6407975
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1998-06-04
Project End
2001-11-30
Budget Start
Budget End
Support Year
3
Fiscal Year
2000
Total Cost
Indirect Cost
Name
State University New York Stony Brook
Department
Type
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
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