This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In the respiratory airways, mucus and mucins, the major glycoprotein component of mucus, are hypersecreted in response to bacterial and viral infections, inflammation and environmental insults. The hypersecretion of mucus requires up regulation of MUC genes and/or increased biosynthesis of mucins. An understanding of which MUC genes aer overexpressed and which MUC mucins are hypersecreted in disease states is an active area of research.
The aim of this proposal is to study the alterration in MUC5 mucin levels in normal and pathological airway secretions. Other specific MUC mucins will be tested as antibody probes become available. In this observational study approximately 104 pediatric patients with viral bronchiolitis, asthma, cystic fibrosis, or bacterial pneumonia will be compared to 26 controls over a period of 3
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