Core A. Clinical examines the natural history of senile dementia of the Alzheimer type (SDAT) and healthy aging in longitudinal samples of carefully assessed subjects, using established clinical, cognitive, and neurological methods. The Core also recruits, evaluates, and supplies subjects to the individual projects in this renewal application. Clinicopathological correlations are enhanced by the Core's emphasis on obtaining autopsy permission from both nondemented and demented subjects. Data from these Core activities are compared, with the assistance of Core D. Biostatistics, with those from Core B. Psychometrics, Core C. Neuropathology, and all Projects to explore the central theme of the Program Project: the behavioral and biomedical correlates of SDAT in comparison with healthy aging. These objectives build on our previous studies in these areas. The study of very old persons (aged 80 years and over) will be expanded by enrolling additional subjects and serially assessing them until autopsy to examine areas of overlap in advanced aging and Alzheimer's disease. Core clinical data, including information obtained by a Retrospective Collateral Dementia Interview in brains obtained from the Body Donor Program or General Autopsy Service, will be correlated with detailed patho-anatomic mapping of markers of neuronal degeneration. Attentional factor affecting memory processing in aging and dementia and the effects of hypoglycemia on memory performance will be studied in Core subjects. The Core will continue to enroll subjects in the very mild stages of SDAT and follow its established samples of subjects, originally entered as controls, to distinguish the earliest clinical manifestations of disease from changes associated with aging and to identify those factors predictive of SDAT.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Saint Louis
United States
Zip Code
Joseph-Mathurin, Nelly; Su, Yi; Blazey, Tyler M et al. (2018) Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease. Alzheimers Dement (Amst) 10:669-677
Pottier, Cyril; Zhou, Xiaolai; Perkerson 3rd, Ralph B et al. (2018) Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. Lancet Neurol 17:548-558
Oxtoby, Neil P; Young, Alexandra L; Cash, David M et al. (2018) Data-driven models of dominantly-inherited Alzheimer's disease progression. Brain 141:1529-1544
Del-Aguila, Jorge L; Fernández, Maria Victoria; Schindler, Suzanne et al. (2018) Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline. J Alzheimers Dis 62:745-756
Bonham, Luke W; Karch, Celeste M; Fan, Chun C et al. (2018) CXCR4 involvement in neurodegenerative diseases. Transl Psychiatry 8:73
Mishra, Shruti; Blazey, Tyler M; Holtzman, David M et al. (2018) Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ?4 genotype. Brain 141:1828-1839
Wildburger, Norelle C; Gyngard, Frank; Guillermier, Christelle et al. (2018) Amyloid-? Plaques in Clinical Alzheimer's Disease Brain Incorporate Stable Isotope Tracer In Vivo and Exhibit Nanoscale Heterogeneity. Front Neurol 9:169
Schindler, Suzanne E; Gray, Julia D; Gordon, Brian A et al. (2018) Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging. Alzheimers Dement 14:1460-1469
Pehlivanova, Marieta; Wolf, Daniel H; Sotiras, Aristeidis et al. (2018) Diminished Cortical Thickness is Associated with Impulsive Choice in Adolescence. J Neurosci :
Weintraub, Sandra; Besser, Lilah; Dodge, Hiroko H et al. (2018) Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord 32:10-17

Showing the most recent 10 out of 911 publications