This Core recruits, enrolls and evaluates all subjects entered into the studies of the program project. It uses established clinical protocols at entry and at all assessments to obtain relevant clinical, neurological, and cognitive data to carefully characterize each subject, including for dementia diagnosis and staging. Core data are used by all Cores and projects to explore the correlates of very mild dementia of the Alzheimer type (DAT) in comparison with healthy brain aging. The Core recruits and maintains adequate samples to supply needed subjects for all projects and other cores. In addition to maintaining the longitudinal sample of subjects 65+years (required in all projects) the Core will recruit a sample of subjects at high risk for dementia (Adult Children Study) ages 45-74 to explore antecendents of Alzheimer disease in Project 2 (Novel Biomarkers to Predict Alzheimer's disease), Project 3 (Attention Profiles in Healthy Aging Early Stage DAT)and 4 (Predicting Cognitive Decline in Healthy Elders). For Project 1 (Dementia Assessment in the Community) a shortened dementia assessment is to be tested in the community and this Core will assess subjects using our established clinical protocols to validate the brief instrument. Through its successful voluntary autopsy program, it supplies Core C: Neuropathology with autopsy material and therefore the neuropatholgic diagnoses for the Projects. Core A: Clinical works closely with Core B: Psychometrics to integrate the clinical and psychometric assessments for all subjects and with CoreD: Biostatistics to ensure appropriate data management. The Core supports Core E: Administrative in promoting scientific interactions among all investigators to accomplish the aims of the program project as a whole.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG003991-23
Application #
7172968
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2006-01-01
Budget End
2006-12-31
Support Year
23
Fiscal Year
2006
Total Cost
$467,234
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Sato, Chihiro; Barthélemy, Nicolas R; Mawuenyega, Kwasi G et al. (2018) Tau Kinetics in Neurons and the Human Central Nervous System. Neuron 97:1284-1298.e7
Day, Gregory S; Gordon, Brian A; Perrin, Richard J et al. (2018) In vivo [18F]-AV-1451 tau-PET imaging in sporadic Creutzfeldt-Jakob disease. Neurology 90:e896-e906
Vardarajan, Badri N; Barral, Sandra; Jaworski, James et al. (2018) Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease. Ann Clin Transl Neurol 5:406-417
Lewczuk, Piotr; Riederer, Peter; O'Bryant, Sid E et al. (2018) Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry. World J Biol Psychiatry 19:244-328
Pottier, Cyril; Zhou, Xiaolai; Perkerson 3rd, Ralph B et al. (2018) Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. Lancet Neurol 17:548-558
Joseph-Mathurin, Nelly; Su, Yi; Blazey, Tyler M et al. (2018) Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease. Alzheimers Dement (Amst) 10:669-677
Del-Aguila, Jorge L; Fernández, Maria Victoria; Schindler, Suzanne et al. (2018) Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline. J Alzheimers Dis 62:745-756
Oxtoby, Neil P; Young, Alexandra L; Cash, David M et al. (2018) Data-driven models of dominantly-inherited Alzheimer's disease progression. Brain 141:1529-1544
Mishra, Shruti; Blazey, Tyler M; Holtzman, David M et al. (2018) Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ?4 genotype. Brain 141:1828-1839
Bonham, Luke W; Karch, Celeste M; Fan, Chun C et al. (2018) CXCR4 involvement in neurodegenerative diseases. Transl Psychiatry 8:73

Showing the most recent 10 out of 911 publications