Abstract

The Animal Resources Core serves three functions: 1. Necropsy of old rats and mice to identify gross pathologic lesions that might interact with brain aging changes. 2. Screening of old rats for motor dysfunctions by the balance beam test. 3. Daily supervision of feeding protocols in the Vivarium that will supply rats (F344 males subject to diet restriction and pergolide treatment as manipulations of basal ganglia aging) for all projects and mice (genetically engineered for deficiencies of GSH).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG009793-10
Application #
6318269
Study Section
Project Start
2000-06-01
Project End
2003-05-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
10
Fiscal Year
2000
Total Cost
$213,943
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Chinta, S J; Lieu, C A; Demaria, M et al. (2013) Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease? J Intern Med 273:429-36
Vali, Shireen; Chinta, Shankar J; Peng, Jun et al. (2008) Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data. Free Radic Biol Med 45:1290-301
Jakowec, Michael W; Nixon, Kerry; Hogg, Elizabeth et al. (2004) Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. J Neurosci Res 76:539-50
Finch, Caleb E (2003) Neurons, glia, and plasticity in normal brain aging. Neurobiol Aging 24 Suppl 1:S123-7; discussion S131
McNeill, Thomas H; Brown, Sally A; Hogg, Elizabeth et al. (2003) Synapse replacement in the striatum of the adult rat following unilateral cortex ablation. J Comp Neurol 467:32-43
Robinson, Siobhan; Freeman, Pierre; Moore, Cynthia et al. (2003) Acute and subchronic MPTP administration differentially affects striatal glutamate synaptic function. Exp Neurol 180:74-87
Jha, Nandita; Kumar, M Jyothi; Boonplueang, Rapee et al. (2002) Glutathione decreases in dopaminergic PC12 cells interfere with the ubiquitin protein degradation pathway: relevance for Parkinson's disease? J Neurochem 80:555-61
Rozovsky, Irina; Hoving, Saske; Anderson, Christopher P et al. (2002) Equine estrogens induce apolipoprotein E and glial fibrillary acidic protein in mixed glial cultures. Neurosci Lett 323:191-4
Finch, C E (2002) Neurons, glia, and plasticity in normal brain aging. Adv Gerontol 10:35-9
Jiang, D; Jha, N; Boonplueang, R et al. (2001) Caspase 3 inhibition attenuates hydrogen peroxide-induced DNA fragmentation but not cell death in neuronal PC12 cells. J Neurochem 76:1745-55

Showing the most recent 10 out of 87 publications