Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG011370-02
Application #
2052543
Study Section
Neuroscience, Behavior and Sociology of Aging Review Committee (NBSA)
Project Start
1995-04-01
Project End
1998-03-31
Budget Start
1996-04-12
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Physiology
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Luo, T David; Alton, Timothy B; Apel, Peter J et al. (2016) Effects of age and insulin-like growth factor-1 on rat neurotrophin receptor expression after nerve injury. Muscle Nerve 54:769-75
Tucsek, Zsuzsanna; Toth, Peter; Sosnowska, Danuta et al. (2014) Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease. J Gerontol A Biol Sci Med Sci 69:1212-26
Masser, Dustin R; Bixler, Georgina V; Brucklacher, Robert M et al. (2014) Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline. J Gerontol A Biol Sci Med Sci 69:1311-24
Sosnowska, Danuta; Richardson, Chris; Sonntag, William E et al. (2014) A heart that beats for 500 years: age-related changes in cardiac proteasome activity, oxidative protein damage and expression of heat shock proteins, inflammatory factors, and mitochondrial complexes in Arctica islandica, the longest-living noncolonial an J Gerontol A Biol Sci Med Sci 69:1448-61
Toth, Peter; Tarantini, Stefano; Tucsek, Zsuzsanna et al. (2014) Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase. Am J Physiol Heart Circ Physiol 306:H299-308
Csiszar, Anna; Gautam, Tripti; Sosnowska, Danuta et al. (2014) Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats. Am J Physiol Heart Circ Physiol 307:H292-306
Csiszar, Anna; Sosnowska, Danuta; Tucsek, Zsuzsanna et al. (2013) Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells. J Gerontol A Biol Sci Med Sci 68:235-49
Ungvari, Zoltan; Tucsek, Zsuzsanna; Sosnowska, Danuta et al. (2013) Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells. J Gerontol A Biol Sci Med Sci 68:877-91
Molina, Doris P; Ariwodola, Olusegun J; Weiner, Jeff L et al. (2013) Growth hormone and insulin-like growth factor-I alter hippocampal excitatory synaptic transmission in young and old rats. Age (Dordr) 35:1575-87
Toth, Peter; Tucsek, Zsuzsanna; Sosnowska, Danuta et al. (2013) Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension. J Cereb Blood Flow Metab 33:1732-42

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