The Administrative Core leads the development of the overarching goals and overall study design for the program project grant (PPG). The Core coordinates the flow of ideas, data, human subjects, tissues and other resources across the PPG. In addition, the Administrative Core is responsible for maintaining the PPG database, provides custom analytic datasets as needed, conducts statistical analyses, and provides consultation for study design and statistical analyses. For the renewal, the PPG has adopted the Uniform Data Set (UDS), developed by the National Alzheimer Coordinating Center, which will facilitate the dissemination of findings to the scientific community.
The specific aims of the Core are two fold: 1. Administrative: a) Develop the overarching scientific goals and strategic plan of the PPG, and leverage outside resources, b) Organize the flow of information, subjects, tissues, and internal resources across the PPG (e.g., facilitate communication, disseminate information), c) Prioritize and monitor the utilization of resources (e.g..coordinate policy, administer the budget, review progress), d) Seek scientific review and guidance via an External Advisory Committee, .e)Ensure respect and safety for human subjects. 2. Statistical design and Data management: a) Provide expertise in study design and statistical analysis to the Cores and Projects, b) manage the PPG database assembled from the Clinical, Imaging, and Neuropathology Cores, c) Institute and maintain procedures for study protocol adherence and data quality assurance, d) Prepare and present specific reports (recruitment reports, follow-up schedules and oversight, data quality reports, data summary reports, final neuropathologic diagnosis), e) Facilitate sharing of data with the scientific community.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Southern California
Los Angeles
United States
Zip Code
Haaksma, Miriam L; Calderón-Larrañaga, Amaia; Olde Rikkert, Marcel G M et al. (2018) Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes. Int J Geriatr Psychiatry 33:1057-1064
La Joie, Renaud; Ayakta, Nagehan; Seeley, William W et al. (2018) Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology. Alzheimers Dement :
Lao, Yi; Nguyen, Binh; Tsao, Sinchai et al. (2017) A T1 and DTI fused 3D corpus callosum analysis in MCI subjects with high and low cardiovascular risk profile. Neuroimage Clin 14:298-307
Ramirez-Gomez, Liliana; Zheng, Ling; Reed, Bruce et al. (2017) Neuropsychological Profiles Differentiate Alzheimer Disease from Subcortical Ischemic Vascular Dementia in an Autopsy-Defined Cohort. Dement Geriatr Cogn Disord 44:1-11
Seo, Sang Won; Ayakta, Nagehan; Grinberg, Lea T et al. (2017) Regional correlations between [11C]PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort. Neuroimage Clin 13:130-137
Durazzo, Timothy C; Korecka, Magdalena; Trojanowski, John Q et al. (2016) Active Cigarette Smoking in Cognitively-Normal Elders and Probable Alzheimer's Disease is Associated with Elevated Cerebrospinal Fluid Oxidative Stress Biomarkers. J Alzheimers Dis 54:99-107
Zheng, Ling; Vinters, Harry V; Mack, Wendy J et al. (2016) Differential effects of ischemic vascular disease and Alzheimer's disease on brain atrophy and cognition. J Cereb Blood Flow Metab 36:204-15
Villeneuve, Sylvia; Rabinovici, Gil D; Cohn-Sheehy, Brendan I et al. (2015) Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation. Brain 138:2020-33
Bron, Esther E; Smits, Marion; van der Flier, Wiesje M et al. (2015) Standardized evaluation of algorithms for computer-aided diagnosis of dementia based on structural MRI: the CADDementia challenge. Neuroimage 111:562-79
Vinters, Harry V (2015) Emerging concepts in Alzheimer's disease. Annu Rev Pathol 10:291-319

Showing the most recent 10 out of 208 publications