The program Project entitled """"""""Neurobiology of Mild Cognitive Impairment in the Elderly"""""""" is entering its eleventh year. The overall goal of the project is the determine the molecular substrate of the onet of cognitive decline in eldery people with mild cognitive impairment prior to the development of frant Alzheimer's disease. To accomplish this goal the program brings together a number of basic and clinical scientists from the Chicago area and outside universities. The project will be based at Rush University Medical Center in Chicago. The Program Project consists of an Administrative and Tissue distribution Core and a Statistics and Data Management Core. In addition the following four research projects complete the program: 1: Neurofibrillary Tangle Evolution in Mild Cognitive Imapairment (Lester """"""""Skip"""""""" Binder, Northwestern University Medical Center, project leader);2) LR11 in Mild Cognitive Impairment (Allan Levey, Emory University, project leader);3) Cholinotrophic Abnormalities and Mild Cognitive Impairment (Elliott Mufson, Project Leader);and 4) Synaptic, Cholinergic and Amyloid Abnormalities and Mild Cognitive impairment (Steven DeKosky, University of Pittsburgh project 1 Leader). Each core will support all of these research projects. Moreover, these projects will receive clinical data and tissue samples from the NIA funded Rush ADCC Neuropahtology and Religious Orders Study Cores for all projects. The results of the data produced by the Program Project will shed new light on the neurobiology of elderly people with mild cognitive impairmnent, the transistion to AD and are will facilitate the translational development of stage-specific therapies for AD.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG014449-15
Application #
8247736
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4 (O2))
Program Officer
Refolo, Lorenzo
Project Start
1997-09-01
Project End
2014-01-31
Budget Start
2012-04-01
Budget End
2014-01-31
Support Year
15
Fiscal Year
2012
Total Cost
$1,827,491
Indirect Cost
$263,798
Name
Rush University Medical Center
Department
Neurosciences
Type
Schools of Medicine
DUNS #
068610245
City
Chicago
State
IL
Country
United States
Zip Code
60612
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