The overall goal of the Statistics and Data Management Core (Core B) is to continue providing the computational and analytic resources to support the overall Program Project Grant (PPG) mission of elucidating the molecular neurobiology of mild cognitive impairment (MCI). More specifically, Core B will assist with study design, tissue selection, data management, statistical analysis, and results interpretation to ensure the success of each PPG investigator. Specifically, the core will provide data management linking existing clinical and neuropathological data from the Rush Religious Orders Study (RROS) housed in the Rush Alzheimer's Disease Core Center (RADCC) with the cellular and molecular findings from the four proposed Program Project Grant (PPG) subprojects. To accomplish this. Core B will: Extract and retrieve relevant data from the RROS clinical and neuropathological databases;expand, document, and maintain a library of PPG laboratory data and merge RROS data with PPG laboratory data for statistical analysis. In addition, the Core B will identify eligible cases based upon inclusion/exclusion criteria specified by the PPG while maintaining blinding of investigators to clinical and pathological diagnoses. Finally, provide statistical support for study design, prepare all analytic data sets across projects, perform statistical analyses as needed, and assure statistical accuracy in interpretation and presentation of results. The statistical research team is experienced in the conduct of neuropathological studies involving human tissue samples and has been working with the PPG for over 12 years.

Public Health Relevance

A centralized database with uniform measurements assures quality data is being collected in this PPG grant. Reliance on experienced statistical advisors for addressing study design and data analysis assures the questions addressed by each subproject are being approached in an optimal and sound manner.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Rush University Medical Center
United States
Zip Code
Mahady, Laura; Nadeem, Muhammad; Malek-Ahmadi, Michael et al. (2018) Frontal Cortex Epigenetic Dysregulation During the Progression of Alzheimer's Disease. J Alzheimers Dis 62:115-131
Mufson, Elliott J; He, Bin; Ginsberg, Stephen D et al. (2018) Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study. J Neurotrauma 35:1260-1271
Alldred, Melissa J; Chao, Helen M; Lee, Sang Han et al. (2018) CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation. Hippocampus 28:251-268
Jeanneteau, Freddy; Barrère, Christian; Vos, Mariska et al. (2018) The Stress-Induced Transcription Factor NR4A1 Adjusts Mitochondrial Function and Synapse Number in Prefrontal Cortex. J Neurosci 38:1335-1350
Mahady, L; Nadeem, M; Malek-Ahmadi, M et al. (2018) HDAC2 dysregulation in the nucleus basalis of Meynert during the progression of Alzheimer's disease. Neuropathol Appl Neurobiol :
Peng, Katherine Y; Pérez-González, Rocío; Alldred, Melissa J et al. (2018) Apolipoprotein E4 genotype compromises brain exosome production. Brain :
Ginsberg, Stephen D; Alldred, Melissa J; Gunnam, Satya M et al. (2018) Expression profiling suggests microglial impairment in human immunodeficiency virus neuropathogenesis. Ann Neurol 83:406-417
Tiernan, Chelsea T; Ginsberg, Stephen D; He, Bin et al. (2018) Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease. Neurobiol Dis 117:125-136
Kaur, Gurjinder; Gauthier, Sebastien A; Perez-Gonzalez, Rocio et al. (2018) Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome. Neurobiol Dis 120:165-173
Jansen, Willemijn J; Wilson, Robert S; Visser, Pieter Jelle et al. (2018) Age and the association of dementia-related pathology with trajectories of cognitive decline. Neurobiol Aging 61:138-145

Showing the most recent 10 out of 293 publications