Core A includes the Administrative unit and Biostatistics & Data Management unit. The goal of the Administrative unit of the Core is to maximize efficient use of investigator time by facilitating preparation of manuscripts, ordering and arranging equipment repair, compliance with institutional requirements (filing of protocols for experiments involving vertebrate animals, and adherence to radiation and biohazard guidelines). All project leaders have their laboratories on the 12th,16th or 17th floors of the P&S Building, and the Administrative Core is in close proximity. An important aspect of the Core's work is coordinating arrangements with collaborating investigators under subcontracts at the Sun Health Research Institute. The Core will be administered by Dr. Yan and her Administrative Coordinator, Ms. Edwards. Ms. Edwards has worked extensively with the investigators and co-investigators over the past 8 years. The Administrative unit of the Core will also be responsible for organizing meetings of internal and external advisory boards, of the monthly seminar program in which leaders in fields relevant to the PPG present their findings and discuss results with project leaders, and of the monthly work-in-progress/journal club meetings. Biostatistics & Data Management unit of the Core is responsible for collecting, archiving, entering, and cataloging incoming data from cores B and C, and projects (1-4), and for production of SAS-readable data sets for biostatistical analysis. The Core will be utilized by all four Projects and Cores B & C, which comprise thePPG.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Columbia University (N.Y.)
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Juranek, Judyta K; Daffu, Gurdip K; Geddis, Matthew S et al. (2016) Soluble RAGE Treatment Delays Progression of Amyotrophic Lateral Sclerosis in SOD1 Mice. Front Cell Neurosci 10:117
Carlson, Emily A; Marquez, Rebecca T; Du, Fang et al. (2015) Overexpression of 17?-hydroxysteroid dehydrogenase type 10 increases pheochromocytoma cell growth and resistance to cell death. BMC Cancer 15:166
Du, Heng; Guo, Lan; Wu, Xiaoping et al. (2014) Cyclophilin D deficiency rescues A?-impaired PKA/CREB signaling and alleviates synaptic degeneration. Biochim Biophys Acta 1842:2517-27
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Borger, Eva; Aitken, Laura; Du, Heng et al. (2013) Is amyloid binding alcohol dehydrogenase a drug target for treating Alzheimer's disease? Curr Alzheimer Res 10:21-9
Juranek, Judyta K; Geddis, Matthew S; Song, Fei et al. (2013) RAGE deficiency improves postinjury sciatic nerve regeneration in type 1 diabetic mice. Diabetes 62:931-43
Carnevale, Daniela; Mascio, Giada; D'Andrea, Ivana et al. (2012) Hypertension induces brain ?-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature. Hypertension 60:188-97
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Fang, Fang; Chen, Xiaochun; Huang, Tianwen et al. (2012) Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model. Biochim Biophys Acta 1822:286-92
Du, Heng; Guo, Lan; Yan, Shirley ShiDu (2012) Synaptic mitochondrial pathology in Alzheimer's disease. Antioxid Redox Signal 16:1467-75

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