PROJECT SUMIVIARY: Core A is the Administrative Core of this Program Project Grant (PPG), which is designed to elucidate mechanisms of brain degeneration in hereditary and sporadic frontotemporal dementia (FTD) or Frontotemporal degeneration (FTLD). As such, Core A exercises fiscal and administrative oversight ofthe PPG, facilitates interactions among PPG investigators to accomplish the research program outlined here, coordinates and integrates activities of the Projects/Cores, and provides mechanisms to advise the Principal Investigator (PI) and Core/Project Leaders of this PPG on their progress towards accomplishing its goals. Budgetary and administrative matters will be handled by Core A personnel, while oversight ofthe progress of each Core/Project and the overall PPG will be accomplished by several complementary mechanisms: 1) Bi-weekly meetings of PPG investigators to review ongoing collaborations;2) Monthly meetings of Core/Project investigators, students, fellows and technicians to review progress, accomplishments and problems that arise;3) Organize visits by external scientific advisory committee members;4) Participation by PPG investigators in annual 1-2 day scientific retreats held by the Centerfor Neurodegenerative Disease Research, Institute on Aging and the Institute of Neurological Sciences at Penn, which include presentations by outside speakers and poster sessions wherein students, fellows and faculty from all fields of clinical/basic neuroscience and aging research present their latest findings in an informal setting;5) Participation by PPG investigators in annual meetings of national scientific organizations to present research from this PPG and keep abreast of related scientific advances on the national and international level. Hence, Core A provides a flexible but cleariy delineated administrative structure to foster and facilitate efforts by PPG . investigators to elucidate mechanisms of brain degeneration in hereditary and sporadic FTD/FTLD.

Public Health Relevance

Administrative Core A is highly relevant to this Program Project Grant (PPG) on frontotemporal lobar degeneration (FTLD) because it exercises fiscal and administrative oversight over this PPG , facilitates interactions among PPG investigators to accomplish the research program on FTLD outlined here, coordinates and integrates activities of the Projects/Cores, and provides mechanisms to advise the Principal Investigator and Core/Project Leaders of this PPG on their progress towards accomplishing its goals.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG017586-12
Application #
8377701
Study Section
Special Emphasis Panel (ZAG1-ZIJ-4)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-02-28
Support Year
12
Fiscal Year
2012
Total Cost
$83,602
Indirect Cost
$31,351
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Besser, Lilah; Kukull, Walter; Knopman, David S et al. (2018) Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set. Alzheimer Dis Assoc Disord 32:351-358
Rennert, Lior; Xie, Sharon X (2018) Cox regression model with doubly truncated data. Biometrics 74:725-733
Sandelius, Åsa; Portelius, Erik; Källén, Åsa et al. (2018) Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology. Alzheimers Dement :
Adler, Daniel H; Wisse, Laura E M; Ittyerah, Ranjit et al. (2018) Characterizing the human hippocampus in aging and Alzheimer's disease using a computational atlas derived from ex vivo MRI and histology. Proc Natl Acad Sci U S A 115:4252-4257
Gibbons, Garrett S; Banks, Rachel A; Kim, Bumjin et al. (2018) Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies. J Neuropathol Exp Neurol 77:216-228
Robinson, John L; Lee, Edward B; Xie, Sharon X et al. (2018) Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain 141:2181-2193
Shi, Min; Tang, Lu; Toledo, Jon B et al. (2018) Cerebrospinal fluid ?-synuclein contributes to the differential diagnosis of Alzheimer's disease. Alzheimers Dement 14:1052-1062
McGurk, L; Mojsilovic-Petrovic, J; Van Deerlin, V M et al. (2018) Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis. Acta Neuropathol Commun 6:84
Lleó, Alberto; Irwin, David J; Illán-Gala, Ignacio et al. (2018) A 2-Step Cerebrospinal Algorithm for the Selection of Frontotemporal Lobar Degeneration Subtypes. JAMA Neurol 75:738-745
Grossman, Murray (2018) Linguistic Aspects of Primary Progressive Aphasia. Annu Rev Linguist 4:377-403

Showing the most recent 10 out of 593 publications