The Administrative Core provides infrastructure support for overall direction of the research programs, appropriate fiscal management of the program, and liaison with other entities. The Core has the following functions;1) Oversight of Research Program. This will be accomplished by monthly meetings ofthe Steering Committee of all investigators. We will invite others to join these meetings where appropriate. This will be supplemented by establishing an Advisory Committee. The Core will organize the meeting of the Advisory Committee that will be held at the University of Pennsylvania every 18 months. The members of this group are;Dr. John Trojanowski (Chairperson;University of Pennsylvania), Dr. Chiara Cirelli (University of Wisconsin), Dr. Thomas Kilduff (SRI International), and Dr. Mark Mattson (National Institute on Aging). 2) Preparation of Manuscripts/Maintenance of Records. This Core will be responsible for preparation of manuscripts and for maintaining all records relevant to the Program Project. The Core will also assist investigators in preparation of audio-visual material;3) Financial Management of the Program. This Core will be responsible for financial management of this Program project. It will maintain financial records, do all purchasing and provide investigators with monthly reports about expenses from their component of the program. This Core will be responsible for developing financial reports for the National Institutes of Health in collaboration with the Office of Research Services;4) Liaison with Other Entities. The Core will facilitate smooth interaction between the Program Project and other relevant entities at the University of Pennsylvania;and 5) Seminar Series and Training Program. The Core staff will play its role in organizing a Journal Club, as well as a seminar series with outside speakers. The Core is involved in organizing an annual one-day Sleep Research Retreat in which faculty, trainees and staff involved in this Program Project participate.

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National Institute on Aging (NIA)
Research Program Projects (P01)
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Special Emphasis Panel (ZAG1-ZIJ-5)
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Naidoo, Nirinjini; Zhu, Jingxu; Galante, Raymond J et al. (2018) Reduction of the molecular chaperone binding immunoglobulin protein (BiP) accentuates the effect of aging on sleep-wake behavior. Neurobiol Aging 69:10-25
Zimmerman, John E; Chan, May T; Lenz, Olivia T et al. (2017) Glutamate Is a Wake-Active Neurotransmitter in Drosophila melanogaster. Sleep 40:
Anafi, Ron C; Francey, Lauren J; Hogenesch, John B et al. (2017) CYCLOPS reveals human transcriptional rhythms in health and disease. Proc Natl Acad Sci U S A 114:5312-5317
Nikonova, Elena V; Gilliland, Jason DA; Tanis, Keith Q et al. (2017) Transcriptional Profiling of Cholinergic Neurons From Basal Forebrain Identifies Changes in Expression of Genes Between Sleep and Wake. Sleep 40:
Havekes, Robbert; Abel, Ted (2017) The tired hippocampus: the molecular impact of sleep deprivation on hippocampal function. Curr Opin Neurobiol 44:13-19
Morgan, Andrew P; Gatti, Daniel M; Najarian, Maya L et al. (2017) Structural Variation Shapes the Landscape of Recombination in Mouse. Genetics 206:603-619
Gerstner, Jason R; Lenz, Olivia; Vanderheyden, William M et al. (2017) Amyloid-? induces sleep fragmentation that is rescued by fatty acid binding proteins in Drosophila. J Neurosci Res 95:1548-1564
Brown, Marishka K; Strus, Ewa; Naidoo, Nirinjini (2017) Reduced Sleep During Social Isolation Leads to Cellular Stress and Induction of the Unfolded Protein Response. Sleep 40:
Gardner, Benjamin; Strus, Ewa; Meng, Qing Cheng et al. (2016) Sleep Homeostasis and General Anesthesia: Are Fruit Flies Well Rested after Emergence from Propofol? Anesthesiology 124:404-16
Havekes, Robbert; Park, Alan J; Tolentino, Rosa E et al. (2016) Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory. J Neurosci 36:8936-46

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