( from the application): We have established a behaviorally and immunologically sophisticated animal model for the concepts being tested in Projects 1 and 2. Our goal is to identify the specific mechanisms and causal pathways through which social isolation and disruption, in interaction with personality, increases risk for specific infectious, malignant and inflammatory diseases at the end of the life span. We hypothesize that risk for age-associated clinical disease increases when an individual?s social environment is not optimal for that particular individual. We will verify that vulnerability to social isolation is a stable individual trait. We will evaluate the roles of three different mechanisms mediating vulnerability to social isolation and risk for accelerated aging and disease (a) differential exposure to isolation during puberty (b) state and trait differences in adrenal and gonadal function and differential recovery in response to threat. We will identify the active social signals that physiologically ameliorate the negative health effects of social isolation in those individuals that are not predisposed to living alone. Finally, we will identify the physiological consequences of social isolation and disruption by measuring (a) adrenal and reproductive steroids mediating their effects, and (b) the specific molecular and cellular mechanisms by which social isolation and disruption impair the innate immune response (proinflammatory cytokines and natural killer cells).

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG018911-02
Application #
6642885
Study Section
Special Emphasis Panel (ZAG1)
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Cacioppo, John T; Cacioppo, Stephanie (2018) The Population-Based Longitudinal Chicago Health, Aging, and Social Relations Study (CHASRS): Study Description and Predictors of Attrition in Older Adults. Arch Sci Psychol 6:21-31
Cole, Steven W; Capitanio, John P; Chun, Katie et al. (2015) Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation. Proc Natl Acad Sci U S A 112:15142-7
Caruso, M J; McClintock, M K; Cavigelli, S A (2014) Temperament moderates the influence of periadolescent social experience on behavior and adrenocortical activity in adult male rats. Horm Behav 66:517-24
Cacioppo, John T; Cacioppo, Stephanie (2014) Social Relationships and Health: The Toxic Effects of Perceived Social Isolation. Soc Personal Psychol Compass 8:58-72
Luhmann, Maike; Hawkley, Louise C; Cacioppo, John T (2014) Thinking About One's Subjective Well-Being: Average Trends and Individual Differences. J Happiness Stud 15:757-781
Cacioppo, John T; Cacioppo, Stephanie; Boomsma, Dorret I (2014) Evolutionary mechanisms for loneliness. Cogn Emot 28:3-21
Powell, Nicole D; Sloan, Erica K; Bailey, Michael T et al. (2013) Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via ?-adrenergic induction of myelopoiesis. Proc Natl Acad Sci U S A 110:16574-9
Cacioppo, Stephanie; Couto, Blas; Bolmont, Mylene et al. (2013) Selective decision-making deficit in love following damage to the anterior insula. Curr Trends Neurol 7:15-19
VanderWeele, Tyler J; Hawkley, Louise C; Cacioppo, John T (2012) On the reciprocal association between loneliness and subjective well-being. Am J Epidemiol 176:777-84
Cacioppo, John T; Cacioppo, Stephanie (2012) The Phenotype of Loneliness. Eur J Dev Psychol 9:446-452

Showing the most recent 10 out of 61 publications