The major goal of this proposal is to use genetically defined animals to show how iron content in the brain is related to iron parameters in the periphery. The animal model to be employed in this research consists of a panel of recombinant inbred (RI) mouse strains, to refine the natural traits relating to high- and low-brain iron concentration. The mandate of this Core is to provide animals with phenotypic characteristics relating to brain iron concentration.
Aim 1. To provide animals, animal tissue and support service for Projects #3 and #4.
Aim 2. To maintain a colony of BXD inbred mice in order to refine the current phenotype or to explore other phenotypic characteristics that are identified in RLS subjects or autopsy material over the ensuing years of the Program Project.
Aim 3. To perform quantitative genetic analysis on nigral brain iron content.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG021190-04
Application #
7433155
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
4
Fiscal Year
2007
Total Cost
$372,763
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Allen, Richard P; Barker, Peter B; Horskรก, Alena et al. (2013) Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep. Neurology 80:2028-34
Jellen, L C; Lu, L; Wang, X et al. (2013) Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice. Neuroscience 252:13-23
Earley, Christopher J; Kuwabara, Hiroto; Wong, Dean F et al. (2013) Increased synaptic dopamine in the putamen in restless legs syndrome. Sleep 36:51-7

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