Abstract

The Administrative and Clinical Core will provide the organizational underpinnings of this project and serve as the primary site for all human subject recruitment and screening for the research projects. It will be responsible for collecting demographic, genetic, clinical, neuropsychological, and structural MRI (used to co-register to PET for PET image analysis) data, as well as other relevant information needed to track and process subjects. Under Dr. Small's direction, the key personnel who will staff this core have worked together for the past decade, successfully providing clinical support for numerous grants funded by the NIH (R01) and other agencies, as well as collaborating with other personnel in the proposed program project. This core will be responsible for database management and statistical consulting; hosting and maintaining the centralized database for the entire program project and making those data available for appropriate project personnel; maintaining quality control and achieving projected project milestones; and serving as the central coordinating body for the entire project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG025831-03
Application #
7434499
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
3
Fiscal Year
2007
Total Cost
$330,865
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Roussotte, Florence F; Siddarth, Prabha; Merrill, David A et al. (2018) In Vivo Brain Plaque and Tangle Burden Mediates the Association Between Diastolic Blood Pressure and Cognitive Functioning in Nondemented Adults. Am J Geriatr Psychiatry 26:13-22
Burggren, Alison C; Mahmood, Zanjbeel; Harrison, Theresa M et al. (2017) Hippocampal thinning linked to longer TOMM40 poly-T variant lengths in the absence of the APOE ?4 variant. Alzheimers Dement 13:739-748
Ghezzi, Chiara; Yu, Amy S; Hirayama, Bruce A et al. (2017) Dapagliflozin Binds Specifically to Sodium-Glucose Cotransporter 2 in the Proximal Renal Tubule. J Am Soc Nephrol 28:802-810
Harrison, Theresa M; Burggren, Alison C; Small, Gary W et al. (2016) Altered memory-related functional connectivity of the anterior and posterior hippocampus in older adults at increased genetic risk for Alzheimer's disease. Hum Brain Mapp 37:366-80
Merrill, David A; Siddarth, Prabha; Raji, Cyrus A et al. (2016) Modifiable Risk Factors and Brain Positron Emission Tomography Measures of Amyloid and Tau in Nondemented Adults with Memory Complaints. Am J Geriatr Psychiatry 24:729-37
Wong, Koon-Pong; Bergsneider, Marvin; Glenn, Thomas C et al. (2016) A semi-automated workflow solution for multimodal neuroimaging: application to patients with traumatic brain injury. Brain Inform 3:1-15
Baerresen, Kimberly M; Miller, Karen J; Hanson, Eric R et al. (2015) Neuropsychological tests for predicting cognitive decline in older adults. Neurodegener Dis Manag 5:191-201
Barrio, Jorge R; Small, Gary W; Wong, Koon-Pong et al. (2015) In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging. Proc Natl Acad Sci U S A 112:E2039-47
Ye, Hu; Wong, Koon-Pong; Wardak, Mirwais et al. (2014) Automated movement correction for dynamic PET/CT images: evaluation with phantom and patient data. PLoS One 9:e103745
Dubal, Dena B; Yokoyama, Jennifer S; Zhu, Lei et al. (2014) Life extension factor klotho enhances cognition. Cell Rep 7:1065-76

Showing the most recent 10 out of 52 publications