Abstract

Core A, the Administrative Core will be the focal point of the three projects and two other cores of the Program. The Administrative Core will provide a variety of key administrative and secretarial functions that are central to each and every project and component of the Program. Since 67% of the Program will be undertaken at Wichita State University, the Administrative Core will be housed on that campus as well under the direction of Dr. George Bousfield, the Principal Investigator of the Program. Extensive administrative experience will be provided by Dr. Jeffrey May, Co-Core Leader. However, the Administrative Core will serve the Projects and Project Leaders on the other campuses, including the Kansas City campus of the University of Kansas Medical Center, Dr. Raj Kumar;and the University of Nebraska Medical Center, Drs. John Davis, S.K. Roy, and E. Bedows. The Administrative Core will organize an annual site visit by the external advisory board. The board has been selected for expertise in gonadotropin structure and function (Dr.James Dias), gonadotropin signal transduction (Dr. Mary Hunzicker-Dunn), gonadotropin molecular biology (Dr. Irving Boime), and FSH isoforms (Dr.Alfredo Ulloa-Aguirre).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG029531-04
Application #
8377833
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
4
Fiscal Year
2012
Total Cost
$125,051
Indirect Cost
$39,400

  Institution

Name
Wichita State University
Department
Type
DUNS #
053078127
City
Wichita
State
KS
Country
United States
Zip Code
67260

  Publications

Das, Nandana; Kumar, T Rajendra (2018) Molecular regulation of follicle-stimulating hormone synthesis, secretion and action. J Mol Endocrinol 60:R131-R155
Gilbert, Sara Babcock; Roof, Allyson K; Rajendra Kumar, T (2018) Mouse models for the analysis of gonadotropin secretion and action. Best Pract Res Clin Endocrinol Metab 32:219-239
Kumar, T Rajendra (2018) Extragonadal Actions of FSH: A Critical Need for Novel Genetic Models. Endocrinology 159:2-8
Roy, Sambit; Gandra, Divya; Seger, Christina et al. (2018) Oocyte-Derived Factors (GDF9 and BMP15) and FSH Regulate AMH Expression Via Modulation of H3K27AC in Granulosa Cells. Endocrinology 159:3433-3445
Kumar, T Rajendra (2018) Fshb Knockout Mouse Model, Two Decades Later and Into the Future. Endocrinology 159:1941-1949
Kumar, T Rajendra (2017) The SO(H)L(H) ""O"" drivers of oocyte growth and survival but not meiosis I. J Clin Invest 127:2044-2047
Romereim, Sarah M; Summers, Adam F; Pohlmeier, William E et al. (2017) Gene expression profiling of bovine ovarian follicular and luteal cells provides insight into cellular identities and functions. Mol Cell Endocrinol 439:379-394
Liu, Peng; Ji, Yaoting; Yuen, Tony et al. (2017) Blocking FSH induces thermogenic adipose tissue and reduces body fat. Nature 546:107-112
Wang, Huizhen; Hastings, Richard; Miller, William L et al. (2016) Fshb-iCre mice are efficient and specific Cre deleters for the gonadotrope lineage. Mol Cell Endocrinol 419:124-38
Wang, Huizhen; May, Jacob; Butnev, Viktor et al. (2016) Evaluation of in vivo bioactivities of recombinant hypo- (FSH21/18) and fully- (FSH24) glycosylated human FSH glycoforms in Fshb null mice. Mol Cell Endocrinol 437:224-236

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