This subproject takes full advantage of the opportunities for cross-study comparison of longitudinal studies in an international context to better understand lifespan contextual influences on later life cognitive and physical functioning. Our focus is on social determinants of individual differences In cognition and health, with emphasis on differential aging risk and exposure processes that affect physical and cognitive ability, cognitive reserve, and cognitive decline. However, because many argue that social factors do not affect age- related physical or cognitive outcomes, but rather select upon them, we will use counterfactual approaches, such as propensity score matching, in addition to standard analytic methods, including multi-level models, to Isolate the effects that socio-demographic processes play In cognition and physical functioning in later life. An important aspect of this project is replication and cross-study comparison of results across studies that differ in birth cohort, resources, geography, and culture. Therefore, this subproject will work closely with Core B to develop and utilize an international contextual database when evaluating results to help contextualize our results in a historically sensitive, comparative and rigorous meta-analytic framework. We will examine the competing and complementary effects of educational attainment, socioeconomic status, and childhood cognition on cognition in later life, and evaluate the role of social and contextual changes across successive birth cohorts. In addition, we will evaluate the Impact of work-related demands, age of retirement, and social class on subsequent level and change in cognitive and physical functioning. The subproject will emphasize inter-cohort and cross-national data analysis to provide results that are broadly generalizable and not subject to biases from small samples or particular contexts, permitting Interpretation of cross-study results In a sociohistorical context.

Public Health Relevance

Recent developments in longitudinal analytic techniques, coupled with a cross-national and Inter-cohort data, will provide new insights into early life causal factors, including socio-demographic factors such as educational attainment, on the development and aging of physical and cognitive capabilities and important occupational and societal outcomes such as unemployment or retirement.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-9)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Oregon Health and Science University
Domestic Higher Education
United States
Zip Code
Nguyen, Madeline T; Mattek, Nora; Woltjer, Randy et al. (2018) Pathologies Underlying Longitudinal Cognitive Decline in the Oldest Old. Alzheimer Dis Assoc Disord 32:265-269
Rawle, Mark James; Davis, Daniel; Bendayan, Rebecca et al. (2018) Apolipoprotein-E (Apoe) ?4 and cognitive decline over the adult life course. Transl Psychiatry 8:18
Karr, Justin E; Areshenkoff, Corson N; Rast, Philippe et al. (2018) The unity and diversity of executive functions: A systematic review and re-analysis of latent variable studies. Psychol Bull 144:1147-1185
Karr, Justin E; Graham, Raquel B; Hofer, Scott M et al. (2018) When does cognitive decline begin? A systematic review of change point studies on accelerated decline in cognitive and neurological outcomes preceding mild cognitive impairment, dementia, and death. Psychol Aging 33:195-218
Weston, Sara J; Hill, Patrick L; Edmonds, Grant W et al. (2018) No Evidence of ""healthy neuroticism"" in the Hawaii Personality and Health Cohort. Ann Behav Med :
Bendayan, Rebecca; Cooper, Rachel; Wloch, Elizabeth G et al. (2017) Hierarchy and Speed of Loss in Physical Functioning: A Comparison Across Older U.S. and English Men and Women. J Gerontol A Biol Sci Med Sci 72:1117-1122
Dodge, Hiroko H; Zhu, Jian; Hughes, Tiffany F et al. (2017) Cohort effects in verbal memory function and practice effects: a population-based study. Int Psychogeriatr 29:137-148
Bendayan, Rebecca; Piccinin, Andrea M; Hofer, Scott M et al. (2017) Are Changes in Self-Rated Health Associated With Memory Decline in Older Adults? J Aging Health 29:1410-1423
Bendayan, Rebecca; Kuh, Diana; Cooper, Rachel et al. (2017) Associations of Childhood and Adulthood Cognition with Bone Mineral Density in Later Adulthood: A Population-Based Longitudinal Study. Front Aging Neurosci 9:241
Cadar, Dorina; Robitaille, Annie; Clouston, Sean et al. (2017) An International Evaluation of Cognitive Reserve and Memory Changes in Early Old Age in 10 European Countries. Neuroepidemiology 48:9-20

Showing the most recent 10 out of 58 publications