Abstract

The Pathology core is subdivided into two parts: (a) a panel of three pathologists (Drs. Page, Kiviat and Crum) who will independently read and score inflammatory changes in endometrial biopsy specimens; and (b) an electron microscopic and organ culture core (Dr. Apicella) that will assist with identification of C. trachomatis and N. gonorrhea in endometrial biopsy specimens and establish organ culture methods to identify cell types invaded by these organisms. This core will also identify the adherence properties of N. gonorrhea that permit attachment and invasion.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI033087-02
Application #
3769690
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Muhlecker, W; Gulati, S; McQuillen, D P et al. (1999) An essential saccharide binding domain for the mAb 2C7 established for Neisseria gonorrhoeae LOS by ES-MS and MSn. Glycobiology 9:157-71
McQuillen, D P; Gulati, S; Ram, S et al. (1999) Complement processing and immunoglobulin binding to Neisseria gonorrhoeae determined in vitro simulates in vivo effects. J Infect Dis 179:124-35
Qureshi, N; Kaltashov, I; Walker, K et al. (1997) Structure of the monophosphoryl lipid A moiety obtained from the lipopolysaccharide of Chlamydia trachomatis. J Biol Chem 272:10594-600
Lo, S K; Golenbock, D T; Sass, P M et al. (1997) Engagement of the Lewis X antigen (CD15) results in monocyte activation. Blood 89:307-14
Gulati, S; McQuillen, D P; Mandrell, R E et al. (1996) Immunogenicity of Neisseria gonorrhoeae lipooligosaccharide epitope 2C7, widely expressed in vivo with no immunochemical similarity to human glycosphingolipids. J Infect Dis 174:1223-37
Gulati, S; McQuillen, D P; Sharon, J et al. (1996) Experimental immunization with a monoclonal anti-idiotope antibody that mimics the Neisseria gonorrhoeae lipooligosaccharide epitope 2C7. J Infect Dis 174:1238-48
Ingalls, R R; Rice, P A; Qureshi, N et al. (1995) The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated. Infect Immun 63:3125-30
Ingalls, R R; Golenbock, D T (1995) CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide. J Exp Med 181:1473-9
Golenbock, D T; Bach, R R; Lichenstein, H et al. (1995) Soluble CD14 promotes LPS activation of CD14-deficient PNH monocytes and endothelial cells. J Lab Clin Med 125:662-71
Delude, R L; Savedra Jr, R; Zhao, H et al. (1995) CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition. Proc Natl Acad Sci U S A 92:9288-92

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