Abstract

A Core for production of VRP and recombinant proteins is proposed for three reasons. First, although production of VRP with the bipartite RNA helper system has reduced the generation of propagation-competent virus by RNA recombination to undetectable levels (a frequency of

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
1P01AI046023-01
Application #
6254602
Study Section
Special Emphasis Panel (ZAI1-KWR-A (M1))
Project Start
1999-09-01
Project End
2004-08-31
Budget Start
Budget End
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Verma, Shefali S; Frase, Alex T; Verma, Anurag et al. (2016) PHENOME-WIDE INTERACTION STUDY (PheWIS) IN AIDS CLINICAL TRIALS GROUP DATA (ACTG). Pac Symp Biocomput 21:57-68
Fluet, M E; Whitmore, A C; Moshkoff, D A et al. (2008) Effects of rapid antigen degradation and VEE glycoprotein specificity on immune responses induced by a VEE replicon vaccine. Virology 370:22-32
Thompson, Joseph M; Nicholson, Michael G; Whitmore, Alan C et al. (2008) Nonmucosal alphavirus vaccination stimulates a mucosal inductive environment in the peripheral draining lymph node. J Immunol 181:574-85
Thompson, Joseph M; Whitmore, Alan C; Staats, Herman F et al. (2008) The contribution of type I interferon signaling to immunity induced by alphavirus replicon vaccines. Vaccine 26:4998-5003
Thompson, Joseph M; Whitmore, Alan C; Staats, Herman F et al. (2008) Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen. Vaccine 26:4267-75
Tang, Y; Swanstrom, R (2008) Development and characterization of a new single cycle vaccine vector in the simian immunodeficiency virus model system. Virology 372:72-84
Cecil, Chad; West, Ande; Collier, Martha et al. (2007) Structure and immunogenicity of alternative forms of the simian immunodeficiency virus gag protein expressed using Venezuelan equine encephalitis virus replicon particles. Virology 362:362-73
Liao, Hua-Xin; Sutherland, Laura L; Xia, Shi-Mao et al. (2006) A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses. Virology 353:268-82
Thompson, Joseph M; Whitmore, Alan C; Konopka, Jennifer L et al. (2006) Mucosal and systemic adjuvant activity of alphavirus replicon particles. Proc Natl Acad Sci U S A 103:3722-7
Johnston, Robert E; Johnson, Philip R; Connell, Mary J et al. (2005) Vaccination of macaques with SIV immunogens delivered by Venezuelan equine encephalitis virus replicon particle vectors followed by a mucosal challenge with SIVsmE660. Vaccine 23:4969-79

Showing the most recent 10 out of 11 publications