The success of the PPG is dependent upon effective communication and efficient interactions between project members. This will be greatly facilitated by a centralized Administrative Core at Yale. Moreover, the Core will facilitate paperwork, forms, approvals, and scheduling matters which will increase efficiency and allow PIs to focus more time on their projects. Administrative Core duties will be carried out by an Administrative Assistant (Ms. Amy Ellis) at Yale, under the direction of Dr. David Rothstein (Core Director). The Administrative Core will be responsible for scheduling and coordinating bimonthly audio-visual conferences and lab meetings between the Pi's at Yale and UPMC. In addition the Administrative Core will be responsible for scheduling site visits by UMPC Pi's Drs. Lakkis and Demetris (three times yearly) to Yale and coordinating these with meetings of the internal advisory committee (twice yearly) and with the external advisory committee (once yearly). This will include arranging travel accommodations and reimbursements for the participants of these meetings as well as making conference arrangement. The Administrative Core will also be responsible for the preparation of joint abstracts, manuscripts, and presentations, and progress reports for the PPG. Other responsibilities include accounting and tracking of expenditures as well as the preparation of the annual budgets for the progress reports. Finally, the Core will be responsible of coordinating the shipping of tissue samples to Dr. Jake Demetris (Histopathology Core B) at UPMC. These duties will ensure seamless communications and interactions between the PI's, the Histopathology Core, and promote effective input from advisory committees. Such interactions are key to the collaborative and interactive environment and communications required for ultimate success of the PPG.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
7P01AI064343-05
Application #
8133175
Study Section
Allergy & Clinical Immunology-1 (AITC)
Project Start
2010-08-01
Project End
2011-07-31
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
5
Fiscal Year
2010
Total Cost
$106,775
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Rothstein, David M; Camirand, Geoffrey (2015) New insights into the mechanisms of Treg function. Curr Opin Organ Transplant 20:376-84
Walch, Jeffrey M; Lakkis, Fadi G (2014) T-cell migration to vascularized organ allografts. Curr Opin Organ Transplant 19:28-32
Camirand, Geoffrey; Wang, Ying; Lu, Yuning et al. (2014) CD45 ligation expands Tregs by promoting interactions with DCs. J Clin Invest 124:4603-13
Oberbarnscheidt, Martin H; Zeng, Qiang; Li, Qi et al. (2014) Non-self recognition by monocytes initiates allograft rejection. J Clin Invest 124:3579-89
Walch, Jeffrey M; Zeng, Qiang; Li, Qi et al. (2013) Cognate antigen directs CD8+ T cell migration to vascularized transplants. J Clin Invest 123:2663-71
Reichenbach, D K; Li, Q; Hoffman, R A et al. (2013) Allograft outcomes in outbred mice. Am J Transplant 13:580-8
Isse, Kumiko; Lesniak, Andrew; Grama, Kedar et al. (2013) Preexisting epithelial diversity in normal human livers: a tissue-tethered cytometric analysis in portal/periportal epithelial cells. Hepatology 57:1632-43
Li, Hongmei; Demetris, Anthony J; McNiff, Jennifer et al. (2012) Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction. J Immunol 188:3804-11
Isse, K; Lesniak, A; Grama, K et al. (2012) Digital transplantation pathology: combining whole slide imaging, multiplex staining and automated image analysis. Am J Transplant 12:27-37
Zecher, Daniel; Li, Qi; Williams, Amanda L et al. (2012) Innate immunity alone is not sufficient for chronic rejection but predisposes healed allografts to T cell-mediated pathology. Transpl Immunol 26:113-8

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