(UC BERKELEY, CORE A) The Administrative Core (Core A) will be responsible for coordinating Program Project (PPG or P01) partners by providing an umbrella infrastructure that will manage overall operations. Effective scientific management and coordination by the Administrative Core will give direction, oversight, and quality assurance for each Project and Core's research activities and will maximize collaboration and exchange among all participating members. Core A will achieve this by ensuring a dynamic interaction among all researchers in the Program Project, specifically, by fostering and facilitating the timely exchange of information, necessary reagents and protocols and sharing of data and will assume financial responsibility for the costs associated with these activities. Core A will promote and mediate regular communication and will facilitate the logistics for scheduled meetings, monthly P01-wide teleconferences, and ad hoc calls. It will also be responsible for arranging and facilitating an annual in-person meeting at the UC Berkeley campus where the overall P01 Director, Project 1, Core A, and Core C are headquartered. In addition, Core A will provide fiscal oversight and general administrative, compliance, and budgetary support for the overall Program Project in coordination with all the administrative designees from the partner institutions. Finally, Core A will coordinate reports to the NIH, ensure compliance with NIH and local institutional requirements, and serve as the primary contact between the P01, the NIAID program officer, and other NIAID staff. Thus, Core A plays a central role in ensuring the smooth administrative functioning of the Program Project as a whole.

Public Health Relevance

(UC BERKELEY, CORE A) Dengue is a major public health problem worldwide, and it is critical to improve our understanding of the human immune response to dengue virus infection and what elements of immune response are associated with protection from or susceptibility to disease. This Program Project should help define immune correlates of protection and contribute to efforts to successfully develop an effective tetravalent dengue vaccine that confers long-term immunity to all four DENV serotypes. The Administrative Core (Core A) will provide crucial coordination functions to ensure regular and fluid exchange of ideas, data, and reagents between P01 investigators as well as compliance with NIH and local institutional requirements.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI106695-05
Application #
9741039
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
5
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Type
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94710
Zambrana, José Victor; Bustos Carrillo, Fausto; Burger-Calderon, Raquel et al. (2018) Seroprevalence, risk factor, and spatial analyses of Zika virus infection after the 2016 epidemic in Managua, Nicaragua. Proc Natl Acad Sci U S A 115:9294-9299
Regla-Nava, Jose Angel; Elong Ngono, Annie; Viramontes, Karla M et al. (2018) Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy. Nat Commun 9:3042
Montoya, Magelda; Collins, Matthew; Dejnirattisai, Wanwisa et al. (2018) Longitudinal Analysis of Antibody Cross-neutralization Following Zika Virus and Dengue Virus Infection in Asia and the Americas. J Infect Dis 218:536-545
Fowler, Angela M; Tang, William W; Young, Matthew P et al. (2018) Maternally Acquired Zika Antibodies Enhance Dengue Disease Severity in Mice. Cell Host Microbe 24:743-750.e5
Burger-Calderon, Raquel; Gonzalez, Karla; Ojeda, Sergio et al. (2018) Zika virus infection in Nicaraguan households. PLoS Negl Trop Dis 12:e0006518
Tsai, Wen-Yang; Youn, Han Ha; Tyson, Jasmine et al. (2018) Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections. Emerg Infect Dis 24:1355-1359
Gallichotte, Emily N; Baric, Thomas J; Yount Jr, Boyd L et al. (2018) Human dengue virus serotype 2 neutralizing antibodies target two distinct quaternary epitopes. PLoS Pathog 14:e1006934
Katzelnick, Leah C; Harris, Eva (2018) The use of longitudinal cohorts for studies of dengue viral pathogenesis and protection. Curr Opin Virol 29:51-61
Goncalves, Adriana; Peeling, Rosanna W; Chu, May C et al. (2018) Innovative and New Approaches to Laboratory Diagnosis of Zika and Dengue: A Meeting Report. J Infect Dis 217:1060-1068
de Silva, Aravinda M; Harris, Eva (2018) Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination? The Path to a Dengue Vaccine: Learning from Human Natural Dengue Infection Studies and Vaccine Trials. Cold Spring Harb Perspect Biol 10:

Showing the most recent 10 out of 54 publications