The Administrative Core (Core A) will provide all scientific, managerial, logistic, and financial oversight to facilitate and to coordinate the studies described in this program. Centralized administration is critical for efficient coordination, management and execution each project. The Administrative Core will ensure that the Adults studies of HIV (Project 1), Pediatric HIV studies (Project 2), the preclinical non-human primate (NHP) studies (Project 3), the Mathematical Modeling and Bioinformatics Core (Core B) adhere to the timelines and deliverables described in those sections. The Administrative Core will organize twice-monthly conference calls and regular in- person meetings among the investigators, interface with clinical sites, maintain regulatory approvals for all preclinical, provide fiscal and logistic oversight, manage subcontracts, and coordinate meetings with the Scientific Advisory Board and DAIDS Program Officials. This detailed administration and management structure will ensure that all the studies remain focused on the overall objective of advancing the understanding of HIV rebound

Public Health Relevance

Centralized administration is critical for efficient project management, coordination and execution. The Administrative Core (Core A) will provide all of the logistic, scientific, managerial, and financial oversight to facilitate and to coordinate the studies described in this DAIDS program. The Administrative Core will ensure that studies in HIV-infected, ART-treated adults (Project 1), pediatric studies of HIV-infected, ART-treated infants (Project 2), preclinical NHP interventional studies (Project 3), Mathematical Modeling and Bioinformatics Core activities (Core B) adhere to the timelines and deliverables described in those sections of this DAIDS program. The Administrative Core will organize bi-monthly conference calls and regular in-person meetings among the investigators, interface with clinical sites, maintain regulatory approvals for all preclinical work, provide fiscal and logistic oversight, manage subcontracts, and coordinate meetings with the Scientific Advisory Board and DAIDS Program Officials. This detailed administration and management structure will ensure that all the studies remain focused on our objective.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI131365-02
Application #
9543317
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2018-08-01
Budget End
2019-07-31
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
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Whitney, James B; Lim, So-Yon; Osuna, Christa E et al. (2018) Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy. Nat Commun 9:5429
Ke, Ruian; Conway, Jessica M; Margolis, David M et al. (2018) Determinants of the efficacy of HIV latency-reversing agents and implications for drug and treatment design. JCI Insight 3:
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