Abstract

This Program Project deals with studies on various aspects of the immune system as they relate to the pathogenesis of the rheumatic diseases. The various projects include studies on the genetic expression, synthesis, and regulation of molecules active in immunopathology. Since most of these projects involve a detailed determination of protein structure, a Core Laboratory has been established to perform amino acid sequencing in an efficient and comprehensive manner on nanamole quantities of proteins. The following Project areas are included: 1. Cell Surface Molecular Chemistry; 2. Complement Biochemistry and Biology; 3. The Immunosuppressive Role of Human Choronic Gonadotrophin; 4. Pathological Immunoglobulins; 5. Characterization of Interleukin I; 6. Neutrophil Proteinases. These projects are interrelated at both conceptual and practical levels, because of our investigation thrusts toward understanding the pathogenesis of rheumatic disease. More importantly, they promise a high level of potential clinical application.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases (NIADDK)
Type
Research Program Projects (P01)
Project #
5P01AM003555-26
Application #
3092240
Study Section
(SRC)
Project Start
1977-12-01
Project End
1986-03-31
Budget Start
1984-12-01
Budget End
1986-03-31
Support Year
26
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Go, M F; Schrohenloher, R E; Tomana, M (1994) Deficient galactosylation of serum IgG in inflammatory bowel disease: correlation with disease activity. J Clin Gastroenterol 18:86-7
Butler, T W; Heck, L W; Berkow, R et al. (1994) Radioimmunometric quantification of surface lactoferrin in blood mononuclear cells. Am J Med Sci 307:102-7
Koopman, W J (1994) The future of biologics in the treatment of rheumatoid arthritis. Semin Arthritis Rheum 23:50-8
O'Sullivan, F X; Koopman, W J; Gay, S (1992) Scanning electron microscopic evaluation of the arthritis in MRL/lpr mice. Rheumatol Int 12:115-20
Hine, R J; Everson, M P; Hardin, J M et al. (1990) Methotrexate therapy in rheumatoid arthritis patients diminishes lectin-induced mononuclear cell proliferation. Rheumatol Int 10:165-9
Brent, L H; Miyawaki, T; Everson, M P et al. (1990) Interleukin 2 production by a marmoset B cell line. Eur J Immunol 20:1125-9
Brent, L H; Butler, J L; Woods Jr, W T et al. (1990) Transmembrane ion conductance in human B lymphocyte activation. J Immunol 145:2381-9
Butler, T W; Grossi, C E; Canessa, A et al. (1990) Immunoreactive lactoferrin in resting, activated, and neoplastic lymphocytes. Leuk Res 14:441-7
Benveniste, E N; Whitaker, J N; Gibbs, D A et al. (1989) Human B cell growth factor enhances proliferation and glial fibrillary acidic protein gene expression in rat astrocytes. Int Immunol 1:219-28
Bhown, A S; Hunter, F; Bennett, J C (1989) Analysis of the spectrin binding domains of globin. Biochem Biophys Res Commun 164:894-902

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