Abstract

The intent of this program-project grant is to investigate the epidemiology of breast cancer and benign breast disease. The work will include: the determination of epidemiologic characteristics of women diagnosed as having different histologically-defined breast conditions; epidemiological and laboratory studies of the secretion of mutagenic substances into breast fluids, including their chemical characterization and potential DNA-damaging and repair activity on cells in human breast fluids and their metabolic activation, and epidemiologic investigations of estrogen-binding beta-globulin in blood and breast fluids.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA013556-14
Application #
3092633
Study Section
(SRC)
Project Start
1977-08-01
Project End
1987-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
14
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Tice, Jeffrey A; Miike, Rei; Adduci, Kelly et al. (2005) Nipple aspirate fluid cytology and the Gail model for breast cancer risk assessment in a screening population. Cancer Epidemiol Biomarkers Prev 14:324-8
King, Eileen B; Chew, Karen L; Hom, John D et al. (2004) Multiple sampling for increasing the diagnostic sensitivity of nipple aspirate fluid for atypical cytology. Acta Cytol 48:813-7
Wrensch, M R; Petrakis, N L; Miike, R et al. (2001) Breast cancer risk in women with abnormal cytology in nipple aspirates of breast fluid. J Natl Cancer Inst 93:1791-8
Lee, M M; Lee, F; Ladenla, S W et al. (1994) A semiquantitative dietary history questionnaire for Chinese Americans. Ann Epidemiol 4:188-97
Petrakis, N L (1993) Nipple aspirate fluid in epidemiologic studies of breast disease. Epidemiol Rev 15:188-95
Petrakis, N L (1993) ASPO Distinguished Achievement Award Lecture. Studies on the epidemiology and natural history of benign breast disease and breast cancer using nipple aspirate fluid. Cancer Epidemiol Biomarkers Prev 2:3-10
Wrensch, M; Petrakis, N L; King, E B et al. (1993) Breast cancer risk associated with abnormal cytology in nipple aspirates of breast fluid and prior history of breast biopsy. Am J Epidemiol 137:829-33
Lee, M M; Wrensch, M R; Miike, R et al. (1992) The association of dietary fat with ability to obtain breast fluid by nipple aspiration. Cancer Epidemiol Biomarkers Prev 1:277-80
Wrensch, M R; Petrakis, N L; King, E B et al. (1992) Breast cancer incidence in women with abnormal cytology in nipple aspirates of breast fluid. Am J Epidemiol 135:130-41
Duarte, L (1991) A new technique facilitating studies of scant cell specimens. Biotech Histochem 66:200-2

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