The themes of this program-project grant are the molecular biology and genetics of viral carcinogenesis and the relationship of the processes involved in viral carcinogenesis and replication to normal cellular processes. Temin and Panganiban work with retroviruses; Mertz and Lambert with papovaviruses; and Sugden with a human herpesvirus. All of the known viruses involved in human cancer (with the exception of hepatitis C virus), are among those studied by this group of investigators. Temin and Panganiban study avian, murine, bovine, and human retroviruses, Lambert and Mertz study bovine and human papillomavirus and simian virus 40, Sugden studies Epstein-Barr virus, and Loeb studies duck and human hepatitis B viruses. The emphasis of each research program within this program-project grant is as follows: Temin studies the genetics of simple and complex retroviruses. Panganiban concentrates on the proteins of primate retroviruses involved in entrance to and exit from cells. Lambert investigates the proteins involved in control of papillomavirus transcription, replication, and transformation. Mertz studies the viral and cellular proteins that control late transcription of simian virus 40, a TATA-less promoter. Sugden's work is concerned with proteins involved in control of Epstein- Barr virus transcription, replication, and transformation. All of these studies will provide much new information for the understanding of evolution, replication, and transformation by these viruses, which either themselves or whose close relatives are involved in human cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA022443-20
Application #
2330672
Study Section
Special Emphasis Panel (SRC (F1))
Project Start
1993-04-16
Project End
1998-01-31
Budget Start
1997-02-01
Budget End
1998-01-31
Support Year
20
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Weng, Chao; Lee, Denis; Gelbmann, Christopher B et al. (2018) Human Cytomegalovirus Productively Replicates In Vitro in Undifferentiated Oral Epithelial Cells. J Virol 92:
Bristol, Jillian A; Djavadian, Reza; Albright, Emily R et al. (2018) A cancer-associated Epstein-Barr virus BZLF1 promoter variant enhances lytic infection. PLoS Pathog 14:e1007179
Romero-Masters, James C; Ohashi, Makoto; Djavadian, Reza et al. (2018) An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model. PLoS Pathog 14:e1007221
UmaƱa, Angie C; Iwahori, Satoko; Kalejta, Robert F (2018) Direct Substrate Identification with an Analog Sensitive (AS) Viral Cyclin-Dependent Kinase (v-Cdk). ACS Chem Biol 13:189-199
Meyers, Jordan M; Grace, Miranda; Uberoi, Aayushi et al. (2018) Inhibition of TGF-? and NOTCH Signaling by Cutaneous Papillomaviruses. Front Microbiol 9:389
Uberoi, Aayushi; Yoshida, Satoshi; Lambert, Paul F (2018) Development of an in vivo infection model to study Mouse papillomavirus-1 (MmuPV1). J Virol Methods 253:11-17
Djavadian, Reza; Hayes, Mitchell; Johannsen, Eric (2018) CAGE-seq analysis of Epstein-Barr virus lytic gene transcription: 3 kinetic classes from 2 mechanisms. PLoS Pathog 14:e1007114
Chakravorty, Adityarup; Sugden, Bill (2018) Long-distance communication: Looping of human papillomavirus genomes regulates expression of viral oncogenes. PLoS Biol 16:e3000062
Chiu, Ya-Fang; Sugden, Bill (2018) Plasmid Partitioning by Human Tumor Viruses. J Virol 92:
Shin, Myeong-Kyun; Payne, Susan N; Bilger, Andrea et al. (2018) Activating Mutations in Pik3caContribute to Anal Carcinogenesis in the Presence or Absence of HPV-16 Oncogenes. Clin Cancer Res :

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