Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA029589-05
Application #
4691267
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Shackelford, R E; Alford, P B; Xue, Y et al. (1997) Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages. Mol Pharmacol 52:421-9
Misra, U K; Gonzalez-Gronow, M; Gawdi, G et al. (1997) Up-regulation of the alpha2-macroglobulin signaling receptor on rheumatoid synovial fibroblasts. J Biol Chem 272:497-502
Howard, G C; Yamaguchi, Y; Misra, U K et al. (1996) Selective mutations in cloned and expressed alpha-macroglobulin receptor binding fragment alter binding to either the alpha2-macroglobulin signaling receptor or the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor. J Biol Chem 271:14105-11
Ali, H; Tomhave, E D; Richardson, R M et al. (1996) Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation. J Biol Chem 271:3200-6
Howard, G C; DeCamp, D L; Misra, U K et al. (1996) Identification of residues in alpha-macroglobulins involved in activation of the alpha 2-macroglobulin signaling receptor. Biochim Biophys Acta 1297:111-4
Howard, G C; Misra, U K; DeCamp, D L et al. (1996) Altered interaction of Cis-dichlorodiammineplatinum(II)--modified alpha 2-macroglobulin (alpha 2M) with the low density lipoprotein receptor-related protein/alpha 2M receptor but not the alpha 2M signaling receptor. J Clin Invest 97:1193-203
Misra, U K; Pizzo, S V (1996) Ligation of the alpha 2-macroglobulin signaling receptor on macrophages induces synthesis of platelet activating factor. J Cell Biochem 61:39-47
Misra, U K; Shackelford, R E; Florine-Casteel, K et al. (1996) Maleylated-BSA induces hydrolysis of PIP2, fluxes of Ca2+, NF-kappaB binding, and transcription of the TNF-alpha gene in murine macrophages. J Leukoc Biol 60:784-92
Wu, S M; Pizzo, S V (1996) Low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor on murine peritoneal macrophages mediates the binding and catabolism of low-density lipoprotein. Arch Biochem Biophys 326:39-47
Misra, U K; Gawdi, G; Pizzo, S V (1996) Binding of rat alpha 1-inhibitor-3-methylamine to the alpha 2-macroglobulin signaling receptor induces second messengers. J Cell Biochem 61:61-71

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