Core - Pharmacology

Hill, Harlan

Abstract

The mission of the Pharmacology Core is to provide analytical and pharmacokinetic support for other projects in the Program. Core staff will coordinate the collection and proper storage of all blood samples for the Program; perform measurements of serum or plasma concentrations of drugs and metabolites; and provide pharmacokinetic analyses for the laboratory projects. By establishing a central facility for planning and coordination of blood sampling protocols and the analytical processing of the numerous blood and other biological samples, this Core will minimize duplication of efforts and sample loss and to maximize success in obtaining the analytical and pharmacokinetic precision and information needed to accomplish the proposed research. High performance liquid chromatographic and gas chromatographic-mass spectrometric assays will measure plasma concentrations of 11 drugs and metabolites for the laboratory research and the clinical research projects. Core staff have established assays for morphine, morphine-3-glucuronide, morphine-6-glucuronide, sufentanil, hydromorphone, alfentanil, fentanyl, butorphanol, nalbuphine and buprenorphine. They will develop a proglumide assay early in the program and improve the buprenorphine assay. Overall, the Pharmacology core will assure dependable, high quality analytical support for the other projects in the Program.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Program Projects (P01)
• Project #: 5P01CA038552-07
• Application #: 3772765
• Support Year: 7
• Fiscal Year: 1993

Institution

• Name: Fred Hutchinson Cancer Research Center
• DUNS #: 075524595
• City: Seattle
• State: WA
• Country: United States
• Zip Code: 98109

Publications

Coda, B A; Brown, M C; Risler, L et al. (1999) Equivalent analgesia and side effects during epidural and pharmacokinetically tailored intravenous infusion with matching plasma alfentanil concentration. Anesthesiology 90:98-108

Coda, B; Tanaka, A; Jacobson, R C et al. (1997) Hydromorphone analgesia after intravenous bolus administration. Pain 71:41-8

Donaldson, G W (1995) The factorial structure and stability of the McGill Pain Questionnaire in patients experiencing oral mucositis following bone marrow transplantation. Pain 62:101-9

Syrjala, K L; Donaldson, G W; Davis, M W et al. (1995) Relaxation and imagery and cognitive-behavioral training reduce pain during cancer treatment: a controlled clinical trial. Pain 63:189-98

Bush, N E; Haberman, M; Donaldson, G et al. (1995) Quality of life of 125 adults surviving 6-18 years after bone marrow transplantation. Soc Sci Med 40:479-90

Coda, B A; Brown, M C; Schaffer, R L et al. (1995) A pharmacokinetic approach to resolving spinal and systemic contributions to epidural alfentanil analgesia and side-effects. Pain 62:329-37

Lloid, M E; Schubert, M M; Myerson, D et al. (1994) Cytomegalovirus infection of the tongue following marrow transplantation. Bone Marrow Transplant 14:99-104

Coda, B A; Brown, M C; Schaffer, R et al. (1994) Pharmacology of epidural fentanyl, alfentanil, and sufentanil in volunteers. Anesthesiology 81:1149-61

Syrjala, K L; Chapko, M K; Vitaliano, P P et al. (1993) Recovery after allogeneic marrow transplantation: prospective study of predictors of long-term physical and psychosocial functioning. Bone Marrow Transplant 11:319-27

Chapman, C R; Gavrin, J (1993) Suffering and its relationship to pain. J Palliat Care 9:5-13