The Clinical Statistics core provides collaborative services in the areas of biostatistics; programming; computation and data management; and data abstraction and medical records management. The biostatisticians will administer the core and collaborate in study and form design, perform interim analyses and monitoring of ongoing studies and experiments, and collaborate in analyses (including methodological work as needed), manuscript preparation and publication. The programming and computer staff will perform the following tasks: maintain a VAX cluster of computers (one 6310 and two 11/750's) with a 4 gigabyte disk farm and the ability to handle 40 simultaneous users, prepare data entry software and file structures for specific autologous projects, consult on the purchase, operation and problems of investigator PC's used for autologous projects, perform statistical software runs under the direction of the biostatisticians, program reporting software, and maintain current and archival datafiles both online and offline. The data abstraction unit consists of individuals with medical records expertise. These individuals perform the following tasks: 1) abstract selected data points for the autologous patients; 2) register patients on protocols (including randomized studies), and 3) maintain and run a research file room for the use of the autologous investigators. The excellent interactions of the current grant period will continue.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Fred Hutchinson Cancer Research Center
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Bensinger, W I (2009) Role of autologous and allogeneic stem cell transplantation in myeloma. Leukemia 23:442-8
Bensinger, William (2008) Stem-cell transplantation for multiple myeloma in the era of novel drugs. J Clin Oncol 26:480-92
Bensinger, William I (2007) Is there still a role for allogeneic stem-cell transplantation in multiple myeloma? Best Pract Res Clin Haematol 20:783-95
Bensinger, William I (2007) Reduced intensity allogeneic stem cell transplantation in multiple myeloma. Front Biosci 12:4384-92
Zaucha, Renata E; Buckner, Dean C; Barnett, Todd et al. (2006) Modified total body irradiation as a planned second high-dose therapy with stem cell infusion for patients with bone-based malignancies. Int J Radiat Oncol Biol Phys 64:227-34
Bensinger, W I (2006) The current status of reduced-intensity allogeneic hematopoietic stem cell transplantation for multiple myeloma. Leukemia 20:1683-9
Bensinger, William I (2004) The role of hematopoietic stem cell transplantation in the treatment of multiple myeloma. J Natl Compr Canc Netw 2:371-8
Bensinger, William I (2004) The current status of hematopoietic stem cell transplantation for multiple myeloma. Clin Adv Hematol Oncol 2:46-52
Yusuf, U; Frangoul, H A; Gooley, T A et al. (2004) Allogeneic bone marrow transplantation in children with myelodysplastic syndrome or juvenile myelomonocytic leukemia: the Seattle experience. Bone Marrow Transplant 33:805-14
Einsele, H; Bamberg, M; Budach, W et al. (2003) A new conditioning regimen involving total marrow irradiation, busulfan and cyclophosphamide followed by autologous PBSCT in patients with advanced multiple myeloma. Bone Marrow Transplant 32:593-9

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