Abstract

The NMR Facilities Core provides the comprehensive technical support required for the execution of the five main projects within the Program Project. The NMR facilities Core also contributes expertise and collaborative assistance on specific technical tasks to be accomplished by various projects and other Cores. This technical support comprises primarily the provision of nonclinical NMR instrument services, but also includes substantial instrumentation development work when projects require capabilities not available on existing instrumentation. Much of this development work is, in fact integral to the research itself. Technical support includes: installation, maintenance, and general supervision of high field and medium bore NMR instruments; development of special purpose RF and gradient coil systems; creation of a PC-based mobile physiological monitoring station; development of an electronic interactive interface for Signa scan control; implementation of high speed imaging on the 2.OT and 4/7 T imagers; and management of the Electronics Shop. All of the construction tasks are carried out in close collaboration with various Projects and/or Cores.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA048729-12
Application #
6300342
Study Section
Project Start
2000-04-01
Project End
2001-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
12
Fiscal Year
2000
Total Cost
$158,814
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Dijkhuizen, Rick M; Singhal, Aneesh B; Mandeville, Joseph B et al. (2003) Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study. J Neurosci 23:510-7
Dijkhuizen, Rick M; Asahi, Minoru; Wu, Ona et al. (2002) Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke 33:2100-4
Atalay, M K; Poncelet, B P; Kantor, H L et al. (2001) Cardiac susceptibility artifacts arising from the heart-lung interface. Magn Reson Med 45:341-5
Dijkhuizen, R M; Ren, J; Mandeville, J B et al. (2001) Functional magnetic resonance imaging of reorganization in rat brain after stroke. Proc Natl Acad Sci U S A 98:12766-71
Dijkhuizen, R M; Asahi, M; Wu, O et al. (2001) Delayed rt-PA treatment in a rat embolic stroke model: diagnosis and prognosis of ischemic injury and hemorrhagic transformation with magnetic resonance imaging. J Cereb Blood Flow Metab 21:964-71
Schellingerhout, D; Rainov, N G; Breakefield, X O et al. (2000) Quantitation of HSV mass distribution in a rodent brain tumor model. Gene Ther 7:1648-55
Marota, J J; Ayata, C; Moskowitz, M A et al. (1999) Investigation of the early response to rat forepaw stimulation. Magn Reson Med 41:247-52
Mandeville, J B; Marota, J J; Ayata, C et al. (1999) Evidence of a cerebrovascular postarteriole windkessel with delayed compliance. J Cereb Blood Flow Metab 19:679-89
Sanchez del Rio, M; Bakker, D; Wu, O et al. (1999) Perfusion weighted imaging during migraine: spontaneous visual aura and headache. Cephalalgia 19:701-7
Poncelet, B P; Koelling, T M; Schmidt, C J et al. (1999) Measurement of human myocardial perfusion by double-gated flow alternating inversion recovery EPI. Magn Reson Med 41:510-9

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