Abstract

The Computing and Technologies core (Core C) is a central focus for data management from all projects. This core provides computer services to Program Project Grant investigators in the form of an Ethernet local area network (LAN) of computer Workstations that is connected to the Harvard Wide Area Network (WAN). Data transfer and analysis tools have been developed to support all of the NMR acquisition systems used by the project investigators. These tools facilitate data analysis, management, storage, graphics, and proper statistical testing. Core C has responsibility for all aspects of computing technology, including equipment maintenance, backup, technology tracking, system advancement, and user education. In addition to computer facility support, Core C supports specific collaborations with investigators who need special purpose programs, data analysis tools, or technical expertise. These include synthetic imaging (diffusion map calculation, functional imaging, blood volume estimation, gamma curve fitting), back projection image reconstruction, mathematical modeling, and statistical support.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA048729-12
Application #
6300336
Study Section
Project Start
2000-04-01
Project End
2001-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
12
Fiscal Year
2000
Total Cost
$158,814
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Dijkhuizen, Rick M; Singhal, Aneesh B; Mandeville, Joseph B et al. (2003) Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study. J Neurosci 23:510-7
Dijkhuizen, Rick M; Asahi, Minoru; Wu, Ona et al. (2002) Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke 33:2100-4
Atalay, M K; Poncelet, B P; Kantor, H L et al. (2001) Cardiac susceptibility artifacts arising from the heart-lung interface. Magn Reson Med 45:341-5
Dijkhuizen, R M; Ren, J; Mandeville, J B et al. (2001) Functional magnetic resonance imaging of reorganization in rat brain after stroke. Proc Natl Acad Sci U S A 98:12766-71
Dijkhuizen, R M; Asahi, M; Wu, O et al. (2001) Delayed rt-PA treatment in a rat embolic stroke model: diagnosis and prognosis of ischemic injury and hemorrhagic transformation with magnetic resonance imaging. J Cereb Blood Flow Metab 21:964-71
Schellingerhout, D; Rainov, N G; Breakefield, X O et al. (2000) Quantitation of HSV mass distribution in a rodent brain tumor model. Gene Ther 7:1648-55
Marota, J J; Ayata, C; Moskowitz, M A et al. (1999) Investigation of the early response to rat forepaw stimulation. Magn Reson Med 41:247-52
Mandeville, J B; Marota, J J; Ayata, C et al. (1999) Evidence of a cerebrovascular postarteriole windkessel with delayed compliance. J Cereb Blood Flow Metab 19:679-89
Sanchez del Rio, M; Bakker, D; Wu, O et al. (1999) Perfusion weighted imaging during migraine: spontaneous visual aura and headache. Cephalalgia 19:701-7
Poncelet, B P; Koelling, T M; Schmidt, C J et al. (1999) Measurement of human myocardial perfusion by double-gated flow alternating inversion recovery EPI. Magn Reson Med 41:510-9

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